Effect of aortic regurgitation following transcatheter aortic valve implantation on outcomes

See Hooi Ewe; Manuela Muratori; Frank Van Der Kley; Mauro Pepi; Victoria Delgado; Gloria Tamborini; Laura Fusini; Arend De Weger; Paola Gripari; Antonio Bartorelli; Jeroen J. Bax; Nina Ajmone Marsan

doi:10.1016/j.amjcard.2014.12.018

Effect of aortic regurgitation following transcatheter aortic valve implantation on outcomes

See Hooi Ewe, Manuela Muratori, Frank Van Der Kley, Mauro Pepi, Victoria Delgado, Gloria Tamborini, Laura Fusini, Arend De Weger, Paola Gripari, Antonio Bartorelli, Jeroen J. Bax, Nina Ajmone Marsan

Centro Cardiologico Monzino

Research output: Contribution to journal › Article › peer-review

Abstract

The prognosis of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) and the changes in AR grade over time remain unclear. This study evaluated the midterm survival associated with AR after TAVI and examined the evolution of AR over time and its effect on cardiac performance. Successful TAVI was performed in 314 patients (age 81 ± 7 years, 36% men). Serial transthoracic echocardiography and clinical assessment were available in 175 patients who survived >12 months. AR was assessed in terms of overall, paravalvular, and intravalvular severity. Significant post-TAVI AR (grade ≥2) was observed in 82 patients (26%), and these patients showed a trend toward reduced survival at 1- (93% vs 91%) and 2-year (89% vs 74%, log-rank p = 0.063) follow-up. Of the 175 patients who survived >12 months, grade ≥2 overall, paravalvular, and intravalvular AR were noted in 47 (27%), 32 (18%), and 8 patients (5%), respectively. Significant overall and paravalvular AR appeared to improve over time, particularly during the first 6 months (p

Original language	English
Pages (from-to)	664-669
Number of pages	6
Journal	The American Journal of Cardiology
Volume	115
Issue number	5
DOIs	https://doi.org/10.1016/j.amjcard.2014.12.018
Publication status	Published - Mar 1 2015

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Medicine(all)

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Effect of aortic regurgitation following transcatheter aortic valve implantation on outcomes. / Ewe, See Hooi; Muratori, Manuela; Van Der Kley, Frank; Pepi, Mauro; Delgado, Victoria; Tamborini, Gloria ; Fusini, Laura; De Weger, Arend; Gripari, Paola ; Bartorelli, Antonio; Bax, Jeroen J.; Marsan, Nina Ajmone.

In: The American Journal of Cardiology, Vol. 115, No. 5, 01.03.2015, p. 664-669.

Research output: Contribution to journal › Article › peer-review

Ewe, See Hooi ; Muratori, Manuela ; Van Der Kley, Frank ; Pepi, Mauro ; Delgado, Victoria ; Tamborini, Gloria ; Fusini, Laura ; De Weger, Arend ; Gripari, Paola ; Bartorelli, Antonio ; Bax, Jeroen J. ; Marsan, Nina Ajmone. / Effect of aortic regurgitation following transcatheter aortic valve implantation on outcomes. In: The American Journal of Cardiology. 2015 ; Vol. 115, No. 5. pp. 664-669.

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abstract = "The prognosis of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) and the changes in AR grade over time remain unclear. This study evaluated the midterm survival associated with AR after TAVI and examined the evolution of AR over time and its effect on cardiac performance. Successful TAVI was performed in 314 patients (age 81 ± 7 years, 36% men). Serial transthoracic echocardiography and clinical assessment were available in 175 patients who survived >12 months. AR was assessed in terms of overall, paravalvular, and intravalvular severity. Significant post-TAVI AR (grade ≥2) was observed in 82 patients (26%), and these patients showed a trend toward reduced survival at 1- (93% vs 91%) and 2-year (89% vs 74%, log-rank p = 0.063) follow-up. Of the 175 patients who survived >12 months, grade ≥2 overall, paravalvular, and intravalvular AR were noted in 47 (27%), 32 (18%), and 8 patients (5%), respectively. Significant overall and paravalvular AR appeared to improve over time, particularly during the first 6 months (p ",

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