Effect of Aortic Valve Surgery on Left Ventricular Diastole Assessed by Echocardiography and Neuroendocrine Response: Percutaneous Versus Surgical Approach

Fabio Guarracino, Enrica Talini, Giovanni Landoni, Sonia Petronio, Cristina Giannini, Vito Di Bello

Research output: Contribution to journalArticle


Objectives: Aortic valve implantation through peripheral vascular access is an option for high-risk patients with severe aortic valve stenosis. The authors aimed to compare the acute effect of endovascular and surgical aortic valve procedures on left ventricular diastolic function. Design: A case-matched, nonrandomized study. Setting: A university hospital. Participants: Patients with aortic stenosis. Interventions: B-natriuretic peptide was measured in 30 patients with a logistic EuroSCORE ≥20% undergoing endovascular aortic valve implantation. Patients were case matched (age, mitral flow propagation velocity, mitral annulus early diastolic velocity, and B-natriuretic peptide measurement) with 30 control patients undergoing surgical aortic valve replacement through sternotomy. Left ventricular diastole was evaluated initially and after valve procedures with echocardiography by mitral flow propagation velocity and mitral annulus early diastolic velocity. Measurements and Main Results: B-natriuretic peptide was similar preoperatively in the 2 groups (346 [188-438] v 367 [211-458] pg/mL) and higher (p = 0.006) in the surgical group postoperatively (389.5 [237-479] v 710.5 [389-822] pg/mL), with a postprocedural statistically significant increase only in the surgical group. Diastolic function was similar in the 2 groups preoperatively, improved postoperatively in the endovascular group, and worsened in the surgical group. Conclusions: B-natriuretic peptide increased after surgical but not after endovascular aortic valve replacement. Furthermore, endovascular aortic valve implantation acutely improved left ventricular diastolic function as documented by increases in mitral flow propagation velocity and mitral annulus early diastolic velocity.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number1
Publication statusPublished - Feb 2010



  • aortic valve replacement
  • aortic valve stenosis
  • B-natriuretic peptide
  • diastole
  • percutaneous

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine

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