Effect of aspirin and sulindac in rabbit nephrotoxic nephritis

Tullio Bertani, Ariela Benigni, Franca Cutillo, Giovanna Rocchi, Carla Morelli, Claudio Carminati, Pierre Verroust, Giuseppe Remuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Glomerular damage in nephrotoxic nephritis is mediated by circulating cells (neutrophils, platelets, and macrophages) infiltrating the glomerular tuft and responsible for the inflammatory reactions. It has been suggested that inflammatory cells may participate in glomerular inflammation through the synthesis and release of elcosanoids derived from the metabolism of arachidonic acid. On the other hand, old data and recent evidence indicate that elcosanoids derived from renal arachidonic acid metabolism play an important role in maintaining hemodynamics, especially in disease conditions. We wanted to evaluate the differential role of arachidonic acid metabolites derived from circulating or renal cells on the evolution of nephrotoxic nephritis. We used a nonselective cyclooxygenase inhibitor, aspirin, which blocks elcosanoid synthesis both in circulating cells and in renal tissue, as compared with a selective cyclooxygenase inhibitor, sulindac, which inhibits arachidonic acid metabolism in circulating cells, partially sparing renal cyclooxygenase. Aspirin, at a dosage that almost completely inhibits both circulating cell and renal arachidonate metabolites, worsens the morphologic expression of rabbit nephrotoxic nephritis and negatively influences the clinical course of the disease. Sulindac, at a dose that suppresses circulating platelet cyclooxygenase activity by 90%, but only partially affects renal prostaglandin synthesis, prevents extracapillary proliferation and reduces proteinuria without negative influence on glomerular hemodynamics.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalThe Journal of Laboratory and Clinical Medicine
Volume107
Issue number3
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

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