Effect of aspirin on the fibrinolytic response in perfused rat hindquarters

Licia Iacoviello, Amalia De Curtis, Concetta Amore, Maria Cristina D'Adamo, Wlodzimierz Buczko, Giovanni de Gaetano, Maria Benedetta Donati

Research output: Contribution to journalArticle

Abstract

The role of aspirin in tissue plasminogen activator (t-PA) release was studied in rats after experimental venous occlusion. For this purpose, we developed a new experimental model which combines a vascular perfusion system (isolated rat hindquarters) with vascular stimulation, namely the application of venous stasis. Application of venous stasis for 30 min induced the release of t-PA from the vascular endothelium into the perfusate (from 0.19 ± 0.05 to 0.39 ± 0.05 UI/ml), reaching a peak 90 s after reperfusion. Aspirin administered to rats 60 min before the experiments (100 mg/kg i.v.), or dissolved in Tyrode solution (100 μM), suppressed 6-keto-prostaglandin F (6-keto-PGF) synthesis (0.38 ± 0.09 in control and

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalEuropean Journal of Pharmacology
Volume229
Issue number1
DOIs
Publication statusPublished - Dec 8 1992

Keywords

  • Aspirin
  • Fibrinolytic activity
  • Venous stasis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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