Effect of Atorvastatin on endothelium-dependent vasodilation in postmenopausal women with average serum cholesterol levels

Giuseppe Mercuro, Sandra Zoncu, Francesca Saiu, Cristiano Sarais, G. M C Rosano

Research output: Contribution to journalArticle

Abstract

After menopause, most healthy women show an impairment of peripheral vasodilation and an increase of plasma cholesterol levels. Statins have been shown to improve endothelial function in hypercholesterolemic men and women. The present study tests whether atorvastatin (10 mg) influences endothelium-dependent vasodilation in postmenopausal normocholesterolemic women. Twenty-eight healthy, postmenopausal women (mean age 51 ± 2 years) with serum total cholesterol and low-density lipoprotein cholesterol within the desirable range entered a double-blind, single-crossover study. Postmenopausal women were randomized to receive either atorvastatin (10 mg/day) or placebo for 10 days and then crossed to the complementary treatment. Endothelium-dependent and -independent responses were assessed by means of strain-gauge plethysmography before and after intra-arterial infusion of acethylcholine (ACh) and sodium nitroprusside, in comparison to physiologic saline. The nitric oxide pathway was evaluated by repeating the infusion of ACh during admininstration of L-arginine and (G)-monomethyl-L-arginine (L-NMMA). Serum lipoproteins were not significantly modified by the active treatment. The vasodilation induced by ACh was significantly higher in the atorvastatin-treated women compared with the placebo-treated group (24 ± 3 vs 13 ± 2 ml/100 ml tissue/min, p

Original languageEnglish
Pages (from-to)747-750
Number of pages4
JournalThe American Journal of Cardiology
Volume90
Issue number7
DOIs
Publication statusPublished - Oct 1 2002

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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