Effect of atrial natriuretic factor on blood pressure, renin, and aldosterone in goldblatt hypertension

Massimo Volpe, Geoffrey Odell, Hollis D. Kleinert, Franco Müller, Maria J. Camargo, John H. Laragh, Thomas Maack, E. Darracott Vaughan, Steven A. Atlas

Research output: Contribution to journalArticle

Abstract

We previously provided evidence that atrial natriuretic factor (ANF) antagonizes angiotensin H-induced vascular contractility and angiotensin H-stimulated aldosterone production by isolated adrenal cells. To examine the importance of these effects in vivo, synthetic ANF (auriculin A) was administered intravenously (2 μg/kg bolus followed by 0.3 μg/kg/min constant infusion) to conscious, unrestrained two-kidney, one-clip and one-kidney, one-clip rats on normal sodium intake and their sham-operated controls. The one-kidney, one-clip rats also were studied on a sodium-deficient diet. Mean blood pressure, plasma renin activity, and plasma aldosterone levels were measured before and after 60-mlnute infusion. In saralasin-responsive two-kidney, one-clip rats (n = 10), ANF administration reduced blood pressure (from 187 ± 11 [SE] to 153 ± 11 mm Hg; p <0.001) and plasma aldosterone levels (from 182 ± 61 to 125 ± 60 ng/dl; p <0.05), while plasma renin activity increased (from 59 ± 16 to 82 ± 20 ng/ml/hr; p <0.05). Lesser changes in blood pressure occurred in saralasin-nonresponsive two-kidney, one-clip rats (149 ± 10 to 143 ± 8 mm Hg; n = 5), sodiumreplete one-kidney, one-clip rats (183 ± 9 to 170 ± 11 mmHg;n = 9), two-kidney sham-operated rats (122 ± 3 to 115 ± 4 mm Hg; n = 8), and one-kidney sham-operated rats (117 ± 3 to 112 ± 3 mm Hg; n = 7). Control plasma renin and aldosterone levels were not elevated in these latter groups and did not change significantly with ANF administration. In sodium-depleted one-kidney, one-clip rats, which became saralasin responsive, ANF administration significantly reduced blood pressure (from 184 ± 11 to 156 ± 12 mm Hg; n = 8), plasma aldosterone levels (from 286 ± 41 to 179 ± 36 ng/dl), and plasma renin activity (from 69 ± 19 to 44 ± 13 ng/ml/hr). These data indicate that ANF has potent antihypertensive and aldosterone-suppressing effects in vivo, irrespective of induced changes in plasma renin activity. Both the vascular and adrenal effects of ANF appear to be enhanced when the activity of the renin-angiotensin system is increased.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalHypertension
Volume7
Issue number3
Publication statusPublished - 1985

Fingerprint

Renovascular Hypertension
Atrial Natriuretic Factor
Aldosterone
Renin
Surgical Instruments
Blood Pressure
Kidney
Saralasin
Sodium
Angiotensins
Blood Vessels
Renin-Angiotensin System
Antihypertensive Agents
Diet

Keywords

  • Angiotensin
  • Auriculin
  • Rats
  • Renovascular hypertension
  • Saralasin

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Volpe, M., Odell, G., Kleinert, H. D., Müller, F., Camargo, M. J., Laragh, J. H., ... Atlas, S. A. (1985). Effect of atrial natriuretic factor on blood pressure, renin, and aldosterone in goldblatt hypertension. Hypertension, 7(3), 43-48.

Effect of atrial natriuretic factor on blood pressure, renin, and aldosterone in goldblatt hypertension. / Volpe, Massimo; Odell, Geoffrey; Kleinert, Hollis D.; Müller, Franco; Camargo, Maria J.; Laragh, John H.; Maack, Thomas; Darracott Vaughan, E.; Atlas, Steven A.

In: Hypertension, Vol. 7, No. 3, 1985, p. 43-48.

Research output: Contribution to journalArticle

Volpe, M, Odell, G, Kleinert, HD, Müller, F, Camargo, MJ, Laragh, JH, Maack, T, Darracott Vaughan, E & Atlas, SA 1985, 'Effect of atrial natriuretic factor on blood pressure, renin, and aldosterone in goldblatt hypertension', Hypertension, vol. 7, no. 3, pp. 43-48.
Volpe M, Odell G, Kleinert HD, Müller F, Camargo MJ, Laragh JH et al. Effect of atrial natriuretic factor on blood pressure, renin, and aldosterone in goldblatt hypertension. Hypertension. 1985;7(3):43-48.
Volpe, Massimo ; Odell, Geoffrey ; Kleinert, Hollis D. ; Müller, Franco ; Camargo, Maria J. ; Laragh, John H. ; Maack, Thomas ; Darracott Vaughan, E. ; Atlas, Steven A. / Effect of atrial natriuretic factor on blood pressure, renin, and aldosterone in goldblatt hypertension. In: Hypertension. 1985 ; Vol. 7, No. 3. pp. 43-48.
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