TY - JOUR
T1 - Effect of autologous blood transfusion on the rate of biochemical recurrence after radical prostatectomy
AU - Gallina, Andrea
AU - Briganti, Alberto
AU - Chun, Felix K H
AU - Walz, Jochen
AU - Hutterer, Georg C.
AU - Erbersdobler, Andreas
AU - Eichelberg, Christian
AU - Schlomm, Thorsten
AU - Ahyai, Sascha A.
AU - Perrotte, Paul
AU - Saad, Fred
AU - Montorsi, Francesco
AU - Huland, Hartwig
AU - Graefen, Markus
AU - Karakiewicz, Pierre I.
PY - 2007/12
Y1 - 2007/12
N2 - OBJECTIVE: To test the association between autologous blood transfusion (ABT) and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large group of contemporary patients. PATIENTS AND METHODS: We analysed 1291 patients treated with RP; Kaplan-Meier analysis was used to graphically explore the association between ABT and BCR. Cox regression models addressed the association between ABT and BCR in univariate and multivariate analyses, after adjusting for preoperative prostate specific antigen level, pathological Gleason sum, extracapsular extension, seminal vesicle invasion and lymph node invasion. RESULTS: Of all patients, 205 (15.4%) received perioperative ABT. The mean (median, range) follow-up was 43.2 (40.9, 0.3-145) months. BCR was recorded in 347 (26.9%) patients and the time to BCR was 25.2 (20.5, 0.3-107) months. Neither in univariate (P = 0.053) nor in multivariate (P = 0.2) Cox regression analyses was ABT a statistically significant or independent predictor of BCR. CONCLUSION: Perioperative ABT does not predispose to a higher rate of BCR in patients after RP.
AB - OBJECTIVE: To test the association between autologous blood transfusion (ABT) and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large group of contemporary patients. PATIENTS AND METHODS: We analysed 1291 patients treated with RP; Kaplan-Meier analysis was used to graphically explore the association between ABT and BCR. Cox regression models addressed the association between ABT and BCR in univariate and multivariate analyses, after adjusting for preoperative prostate specific antigen level, pathological Gleason sum, extracapsular extension, seminal vesicle invasion and lymph node invasion. RESULTS: Of all patients, 205 (15.4%) received perioperative ABT. The mean (median, range) follow-up was 43.2 (40.9, 0.3-145) months. BCR was recorded in 347 (26.9%) patients and the time to BCR was 25.2 (20.5, 0.3-107) months. Neither in univariate (P = 0.053) nor in multivariate (P = 0.2) Cox regression analyses was ABT a statistically significant or independent predictor of BCR. CONCLUSION: Perioperative ABT does not predispose to a higher rate of BCR in patients after RP.
KW - Autologous blood transfusion
KW - Biochemical recurrence
KW - Prostate cancer
KW - Radical prostatectomy
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U2 - 10.1111/j.1464-410X.2007.07147.x
DO - 10.1111/j.1464-410X.2007.07147.x
M3 - Article
C2 - 17850374
AN - SCOPUS:35748936734
VL - 100
SP - 1249
EP - 1253
JO - BJU International
JF - BJU International
SN - 1464-4096
IS - 6
ER -