Effect of autologous transplantation of bone marrow cells concentrated with the MarrowXpress system in patients with critical limb ischemia

C. Maione, C. Botti, C. A. Coppola, C. Silvestroni, S. Lillo, V. Schiavone, G. Sica, V. Sica, V. Kumar, G. Cobellis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Critical limb ischemia (CLI), a vascular disease affecting lower limbs, with high morbidity and mortality, is becoming a challenge due to the aging of the population. Patients without direct revascularization options have the worst outcomes. To date, 25% to 40% of CLI patients are not candidates for surgical or endovascular approaches, facing a major amputation as the ultimate option. This study sought to assess the safety and efficacy of transplantation of autologous bone marrow concentrates in "no-option" patients to restore blood perfusion by collateral flow and limb salvage. We performed a nonrandomized, noncontrolled pilot study for no-option CLI patients using intra-arterial infusion of autologous bone marrow concentrate. Variation of blood perfusion parameters, evaluated by laser doppler flowmetry after 6 and 12 months, was set as primary endpoint. Thirteen enrolled patients showed improvements in objective measurements of perfusion. This uncontrolled study provided evidence that transplantation of autologous bone marrow concentrates was well tolerated by CLI patients without significant adverse effects, demonstrating improved perfusion, confirming the feasibility and safety of the procedure.

Original languageEnglish
Pages (from-to)402-406
Number of pages5
JournalTransplantation Proceedings
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Autologous Transplantation
Bone Marrow Cells
Ischemia
Extremities
Perfusion
Bone Marrow Transplantation
Safety
Intra Arterial Infusions
Limb Salvage
Laser-Doppler Flowmetry
Vascular Diseases
Amputation
Lower Extremity
Bone Marrow
Morbidity
Mortality
Population

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Effect of autologous transplantation of bone marrow cells concentrated with the MarrowXpress system in patients with critical limb ischemia. / Maione, C.; Botti, C.; Coppola, C. A.; Silvestroni, C.; Lillo, S.; Schiavone, V.; Sica, G.; Sica, V.; Kumar, V.; Cobellis, G.

In: Transplantation Proceedings, Vol. 45, No. 1, 01.2013, p. 402-406.

Research output: Contribution to journalArticle

Maione, C, Botti, C, Coppola, CA, Silvestroni, C, Lillo, S, Schiavone, V, Sica, G, Sica, V, Kumar, V & Cobellis, G 2013, 'Effect of autologous transplantation of bone marrow cells concentrated with the MarrowXpress system in patients with critical limb ischemia', Transplantation Proceedings, vol. 45, no. 1, pp. 402-406. https://doi.org/10.1016/j.transproceed.2012.10.031
Maione, C. ; Botti, C. ; Coppola, C. A. ; Silvestroni, C. ; Lillo, S. ; Schiavone, V. ; Sica, G. ; Sica, V. ; Kumar, V. ; Cobellis, G. / Effect of autologous transplantation of bone marrow cells concentrated with the MarrowXpress system in patients with critical limb ischemia. In: Transplantation Proceedings. 2013 ; Vol. 45, No. 1. pp. 402-406.
@article{f17d723f7e9443bebd0434a90d2ec47c,
title = "Effect of autologous transplantation of bone marrow cells concentrated with the MarrowXpress system in patients with critical limb ischemia",
abstract = "Critical limb ischemia (CLI), a vascular disease affecting lower limbs, with high morbidity and mortality, is becoming a challenge due to the aging of the population. Patients without direct revascularization options have the worst outcomes. To date, 25{\%} to 40{\%} of CLI patients are not candidates for surgical or endovascular approaches, facing a major amputation as the ultimate option. This study sought to assess the safety and efficacy of transplantation of autologous bone marrow concentrates in {"}no-option{"} patients to restore blood perfusion by collateral flow and limb salvage. We performed a nonrandomized, noncontrolled pilot study for no-option CLI patients using intra-arterial infusion of autologous bone marrow concentrate. Variation of blood perfusion parameters, evaluated by laser doppler flowmetry after 6 and 12 months, was set as primary endpoint. Thirteen enrolled patients showed improvements in objective measurements of perfusion. This uncontrolled study provided evidence that transplantation of autologous bone marrow concentrates was well tolerated by CLI patients without significant adverse effects, demonstrating improved perfusion, confirming the feasibility and safety of the procedure.",
author = "C. Maione and C. Botti and Coppola, {C. A.} and C. Silvestroni and S. Lillo and V. Schiavone and G. Sica and V. Sica and V. Kumar and G. Cobellis",
year = "2013",
month = "1",
doi = "10.1016/j.transproceed.2012.10.031",
language = "English",
volume = "45",
pages = "402--406",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "1",

}

TY - JOUR

T1 - Effect of autologous transplantation of bone marrow cells concentrated with the MarrowXpress system in patients with critical limb ischemia

AU - Maione, C.

AU - Botti, C.

AU - Coppola, C. A.

AU - Silvestroni, C.

AU - Lillo, S.

AU - Schiavone, V.

AU - Sica, G.

AU - Sica, V.

AU - Kumar, V.

AU - Cobellis, G.

PY - 2013/1

Y1 - 2013/1

N2 - Critical limb ischemia (CLI), a vascular disease affecting lower limbs, with high morbidity and mortality, is becoming a challenge due to the aging of the population. Patients without direct revascularization options have the worst outcomes. To date, 25% to 40% of CLI patients are not candidates for surgical or endovascular approaches, facing a major amputation as the ultimate option. This study sought to assess the safety and efficacy of transplantation of autologous bone marrow concentrates in "no-option" patients to restore blood perfusion by collateral flow and limb salvage. We performed a nonrandomized, noncontrolled pilot study for no-option CLI patients using intra-arterial infusion of autologous bone marrow concentrate. Variation of blood perfusion parameters, evaluated by laser doppler flowmetry after 6 and 12 months, was set as primary endpoint. Thirteen enrolled patients showed improvements in objective measurements of perfusion. This uncontrolled study provided evidence that transplantation of autologous bone marrow concentrates was well tolerated by CLI patients without significant adverse effects, demonstrating improved perfusion, confirming the feasibility and safety of the procedure.

AB - Critical limb ischemia (CLI), a vascular disease affecting lower limbs, with high morbidity and mortality, is becoming a challenge due to the aging of the population. Patients without direct revascularization options have the worst outcomes. To date, 25% to 40% of CLI patients are not candidates for surgical or endovascular approaches, facing a major amputation as the ultimate option. This study sought to assess the safety and efficacy of transplantation of autologous bone marrow concentrates in "no-option" patients to restore blood perfusion by collateral flow and limb salvage. We performed a nonrandomized, noncontrolled pilot study for no-option CLI patients using intra-arterial infusion of autologous bone marrow concentrate. Variation of blood perfusion parameters, evaluated by laser doppler flowmetry after 6 and 12 months, was set as primary endpoint. Thirteen enrolled patients showed improvements in objective measurements of perfusion. This uncontrolled study provided evidence that transplantation of autologous bone marrow concentrates was well tolerated by CLI patients without significant adverse effects, demonstrating improved perfusion, confirming the feasibility and safety of the procedure.

UR - http://www.scopus.com/inward/record.url?scp=84873279901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873279901&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2012.10.031

DO - 10.1016/j.transproceed.2012.10.031

M3 - Article

C2 - 23375329

AN - SCOPUS:84873279901

VL - 45

SP - 402

EP - 406

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 1

ER -