Effect of blood-brain barrier and blood-tumor barrier modification on central nervous system liposomal uptake

Rosemaria Gennuso, Melvin K. Spigelman, Marco Chinol, Rosario A. Zappulla, Julia Nieves, Shankar Vallabhajosula, P. Alberto Paciucci, Stanley J. Goldsmith, James F. Holland

Research output: Contribution to journalArticle

Abstract

In this study of 25 central nervous system (CNS) tumor-bearing rats, the CNS biodistribution of intravenously administered, indium-labeled liposomes was investigated. In 16 animals, the blood-brain barrier and blood-tumor barrier were modified using intracarotid administration of etoposide. In control animals, analysis by autoradiography and well-counting experiments demonstrated uptake of liposomes in the tumor-bearing hemisphere (% injected dose/g tissue = 0.135) with minimal uptake in the non-tumor-bearing hemisphere (% injected doselg tissue = 0.007), p <0.01. Unilaterul intracurotid etoposide administration enhanced li-posome uptake in both hemispheres-0.215 and 0.023 (tumor-bearing and non-tumor-bearing), respectively. The presence of meningeal tumor involvement in non-tumor-implanted hemispheres increased liposomul uptake IO-fold. These findings may have clinical applicability in designing therapeutic protocols for the treatment of CNS tumors.

Original languageEnglish
Pages (from-to)118-128
Number of pages11
JournalCancer Investigation
Volume11
Issue number2
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Gennuso, R., Spigelman, M. K., Chinol, M., Zappulla, R. A., Nieves, J., Vallabhajosula, S., Paciucci, P. A., Goldsmith, S. J., & Holland, J. F. (1993). Effect of blood-brain barrier and blood-tumor barrier modification on central nervous system liposomal uptake. Cancer Investigation, 11(2), 118-128. https://doi.org/10.3109/07357909309024829