TY - JOUR
T1 - Effect of Blood Hematocrit and Erythrocyte Deformability on Adenosine 5′-Diphosphate Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy
AU - Cecchi, Emanuele
AU - Marcucci, Rossella
AU - Paniccia, Rita
AU - Bandinelli, Brunella
AU - Valente, Serafina
AU - Giglioli, Cristina
AU - Lazzeri, Chiara
AU - Gensini, Gian Franco
AU - Abbate, Rosanna
AU - Mannini, Lucia
PY - 2009/9/15
Y1 - 2009/9/15
N2 - Previous studies have explored the association between hemorheologic alterations and aspirin resistance, pointing out the possible interaction between hematologic components and platelet responsiveness to antiplatelet drugs. The aim of this study was to evaluate the association between hemorheologic variables and residual platelet reactivity in patients with acute coronary syndromes (ACSs) who underwent percutaneous coronary intervention on dual antiplatelet therapy. The study population included 528 patients with ACSs. Hemorheologic studies were performed by assessing whole blood viscosity at 0.512 and 94.5/second, plasma viscosity, and erythrocyte deformability index. Post-treatment platelet reactivity was investigated by measuring platelet aggregation by adenosine 5′-diphosphate (ADP) 10 μmol and a value >70% was defined as high ADP platelet reactivity. Significantly (p
AB - Previous studies have explored the association between hemorheologic alterations and aspirin resistance, pointing out the possible interaction between hematologic components and platelet responsiveness to antiplatelet drugs. The aim of this study was to evaluate the association between hemorheologic variables and residual platelet reactivity in patients with acute coronary syndromes (ACSs) who underwent percutaneous coronary intervention on dual antiplatelet therapy. The study population included 528 patients with ACSs. Hemorheologic studies were performed by assessing whole blood viscosity at 0.512 and 94.5/second, plasma viscosity, and erythrocyte deformability index. Post-treatment platelet reactivity was investigated by measuring platelet aggregation by adenosine 5′-diphosphate (ADP) 10 μmol and a value >70% was defined as high ADP platelet reactivity. Significantly (p
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U2 - 10.1016/j.amjcard.2009.05.005
DO - 10.1016/j.amjcard.2009.05.005
M3 - Article
C2 - 19733708
AN - SCOPUS:69449107151
VL - 104
SP - 764
EP - 768
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 6
ER -