Effect of bombesin on basal and stimulated secretion of some pituitary hormones in humans

Antonio E. Pontiroli, Cannelo Scarpignato

Research output: Contribution to journalArticle

Abstract

The effect of bombesin (5 ng/kg/min × 2.5 h) on basal pituitary secretion as well as on the response to thyrotropin releasing hormone (TRH; 200 pg) plus luteinizing hormone releasing hormone (LHRH; 100 pg) was studied in healthy male volunteers. The peptide did not change the basal level of growth hormone (GH), prolactin, thyroid-stimulating hormone (TSH), luteinizing hormone (LH) and follicle-stimulating hormone (FSH). On the contrary, the pituitary response to releasing hormones was modified by bombesin administration. When compared with control (saline) values, prolactin and TSH levels after TRH were lower during bombesin infusion, whereas LH and FSH levels after LHRH were higher. Thus bombesin affects in man, as in experimental animals, the secretion of some pituitary hormones.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalHormone Research in Paediatrics
Volume23
Issue number3
DOIs
Publication statusPublished - 1986

Keywords

  • Bombesin
  • Follicle stimulating hormone
  • Growth hormone
  • Luteinizing hormone
  • Pituitary secretion
  • Prolactin
  • Thyroid-stimulating hormone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

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