Abstract
Thirty seven patients with established cirrhosis of the liver were subjected to measurement of body protein metabolism using L-(1-14C) labelled leucine as a tracer. The effects of disease severity and those of solutions containing 0%, 16%, 35%, 53%, and 100% branched chain amino acids were evaluated. Significant increases in protein synthesis were noted with solutions containing 35%, 53%, and 100% branched chain amino acids, but in patients receiving 100% branched chain amino acids without additional essential amino acid supplement the increase in synthesis was matched by a significant increase in protein breakdown. Protein balance was thus improved only in patients receiving 35% and 53% branched chain amino acids. It was concluded that the high increase in protein breakdown in patients receiving 100% branched chain amino acids was undesirable, and such a solution should not be recommended for clinical use.
| Original language | English |
|---|---|
| Pages (from-to) | 96-102 |
| Number of pages | 7 |
| Journal | Gut |
| Volume | 27 |
| Issue number | SUPPL. 1 |
| DOIs | |
| Publication status | Published - 1986 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Gastroenterology
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Effect of branched chain amino acid infusions on body protein metabolism in cirrhosis of liver. / Wright, P. D.; Holdsworth, J. D.; Dionigi, P.; Clague, M. B.; James, O. F W.
In: Gut, Vol. 27, No. SUPPL. 1, 1986, p. 96-102.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of branched chain amino acid infusions on body protein metabolism in cirrhosis of liver
AU - Wright, P. D.
AU - Holdsworth, J. D.
AU - Dionigi, P.
AU - Clague, M. B.
AU - James, O. F W
PY - 1986
Y1 - 1986
N2 - Thirty seven patients with established cirrhosis of the liver were subjected to measurement of body protein metabolism using L-(1-14C) labelled leucine as a tracer. The effects of disease severity and those of solutions containing 0%, 16%, 35%, 53%, and 100% branched chain amino acids were evaluated. Significant increases in protein synthesis were noted with solutions containing 35%, 53%, and 100% branched chain amino acids, but in patients receiving 100% branched chain amino acids without additional essential amino acid supplement the increase in synthesis was matched by a significant increase in protein breakdown. Protein balance was thus improved only in patients receiving 35% and 53% branched chain amino acids. It was concluded that the high increase in protein breakdown in patients receiving 100% branched chain amino acids was undesirable, and such a solution should not be recommended for clinical use.
AB - Thirty seven patients with established cirrhosis of the liver were subjected to measurement of body protein metabolism using L-(1-14C) labelled leucine as a tracer. The effects of disease severity and those of solutions containing 0%, 16%, 35%, 53%, and 100% branched chain amino acids were evaluated. Significant increases in protein synthesis were noted with solutions containing 35%, 53%, and 100% branched chain amino acids, but in patients receiving 100% branched chain amino acids without additional essential amino acid supplement the increase in synthesis was matched by a significant increase in protein breakdown. Protein balance was thus improved only in patients receiving 35% and 53% branched chain amino acids. It was concluded that the high increase in protein breakdown in patients receiving 100% branched chain amino acids was undesirable, and such a solution should not be recommended for clinical use.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022975988&partnerID=8YFLogxK
U2 - 10.1136/gut.27.Suppl_1.96
DO - 10.1136/gut.27.Suppl_1.96
M3 - Article
C2 - 3539714
AN - SCOPUS:0022975988
VL - 27
SP - 96
EP - 102
JO - Gut
JF - Gut
SN - 0017-5749
IS - SUPPL. 1
ER -