Effect of branched chain amino acid infusions on body protein metabolism in cirrhosis of liver

P. D. Wright, J. D. Holdsworth, P. Dionigi, M. B. Clague, O. F W James

Research output: Contribution to journalArticle

Abstract

Thirty seven patients with established cirrhosis of the liver were subjected to measurement of body protein metabolism using L-(1-14C) labelled leucine as a tracer. The effects of disease severity and those of solutions containing 0%, 16%, 35%, 53%, and 100% branched chain amino acids were evaluated. Significant increases in protein synthesis were noted with solutions containing 35%, 53%, and 100% branched chain amino acids, but in patients receiving 100% branched chain amino acids without additional essential amino acid supplement the increase in synthesis was matched by a significant increase in protein breakdown. Protein balance was thus improved only in patients receiving 35% and 53% branched chain amino acids. It was concluded that the high increase in protein breakdown in patients receiving 100% branched chain amino acids was undesirable, and such a solution should not be recommended for clinical use.

Original languageEnglish
Pages (from-to)96-102
Number of pages7
JournalGut
Volume27
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1986

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

Cite this

Wright, P. D., Holdsworth, J. D., Dionigi, P., Clague, M. B., & James, O. F. W. (1986). Effect of branched chain amino acid infusions on body protein metabolism in cirrhosis of liver. Gut, 27(SUPPL. 1), 96-102. https://doi.org/10.1136/gut.27.Suppl_1.96