Effect of cabergoline added to levodopa treatment on sleep-wake cycle in idiopathic Parkinson's disease

An open label 24-hour polysomnographic study

A. Romigi, P. Stanzione, M. G. Marciani, F. Izzi, F. Placidi, A. Cervellino, P. Giacomini, L. Brusa, K. Grossi, M. Pierantozzi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Few studies focused on the effects of cabergoline on sleep-wake cycle in PD. Twelve patients affected by PD treated with levodopa as monotherapy underwent two 24-hour ambulatory polysomnographic (A-PSG) sessions twice: in baseline condition (levodopa as monotherapy) and after addition of cabergoline. In each condition, a subjective evaluation of sleep quality and daytime sleepiness was obtained by means of Parkinson's disease Sleep Scale (PDSS) and the Epworth Sleepiness Scale. The statistical analysis of sleep parameters revealed a significant increase of sleep efficiency and slow wave sleep under cabergoline. The PDSS total score showed a significant improvement of overall sleep quality after cabergoline. No significant changes in daytime sleepiness were observed. No patient referred and/or showed sleep attacks before and after addition of cabergoline. We hypothesize that the long-lasting effect of cabergoline may improve the objective quality of nocturnal sleep in PD patients complaining nocturnal motor disability without inducing daytime sleepiness.

Original languageEnglish
Pages (from-to)1909-1913
Number of pages5
JournalJournal of Neural Transmission
Volume113
Issue number12
DOIs
Publication statusPublished - Dec 2006

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Levodopa
Parkinson Disease
Sleep
Therapeutics
cabergoline

Keywords

  • Cabergoline
  • Epworth Sleepiness Scale
  • Excessive daytime somnolence
  • Parkinson's disease
  • Parkinson's disease Sleep Scale
  • Polysomnography
  • Sleep

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effect of cabergoline added to levodopa treatment on sleep-wake cycle in idiopathic Parkinson's disease : An open label 24-hour polysomnographic study. / Romigi, A.; Stanzione, P.; Marciani, M. G.; Izzi, F.; Placidi, F.; Cervellino, A.; Giacomini, P.; Brusa, L.; Grossi, K.; Pierantozzi, M.

In: Journal of Neural Transmission, Vol. 113, No. 12, 12.2006, p. 1909-1913.

Research output: Contribution to journalArticle

Romigi, A, Stanzione, P, Marciani, MG, Izzi, F, Placidi, F, Cervellino, A, Giacomini, P, Brusa, L, Grossi, K & Pierantozzi, M 2006, 'Effect of cabergoline added to levodopa treatment on sleep-wake cycle in idiopathic Parkinson's disease: An open label 24-hour polysomnographic study', Journal of Neural Transmission, vol. 113, no. 12, pp. 1909-1913. https://doi.org/10.1007/s00702-006-0490-x
Romigi, A. ; Stanzione, P. ; Marciani, M. G. ; Izzi, F. ; Placidi, F. ; Cervellino, A. ; Giacomini, P. ; Brusa, L. ; Grossi, K. ; Pierantozzi, M. / Effect of cabergoline added to levodopa treatment on sleep-wake cycle in idiopathic Parkinson's disease : An open label 24-hour polysomnographic study. In: Journal of Neural Transmission. 2006 ; Vol. 113, No. 12. pp. 1909-1913.
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