Effect of cabergoline added to levodopa treatment on sleep-wake cycle in idiopathic Parkinson's disease: An open label 24-hour polysomnographic study

A. Romigi, P. Stanzione, M. G. Marciani, F. Izzi, F. Placidi, A. Cervellino, P. Giacomini, L. Brusa, K. Grossi, M. Pierantozzi

Research output: Contribution to journalArticle

Abstract

Few studies focused on the effects of cabergoline on sleep-wake cycle in PD. Twelve patients affected by PD treated with levodopa as monotherapy underwent two 24-hour ambulatory polysomnographic (A-PSG) sessions twice: in baseline condition (levodopa as monotherapy) and after addition of cabergoline. In each condition, a subjective evaluation of sleep quality and daytime sleepiness was obtained by means of Parkinson's disease Sleep Scale (PDSS) and the Epworth Sleepiness Scale. The statistical analysis of sleep parameters revealed a significant increase of sleep efficiency and slow wave sleep under cabergoline. The PDSS total score showed a significant improvement of overall sleep quality after cabergoline. No significant changes in daytime sleepiness were observed. No patient referred and/or showed sleep attacks before and after addition of cabergoline. We hypothesize that the long-lasting effect of cabergoline may improve the objective quality of nocturnal sleep in PD patients complaining nocturnal motor disability without inducing daytime sleepiness.

Original languageEnglish
Pages (from-to)1909-1913
Number of pages5
JournalJournal of Neural Transmission
Volume113
Issue number12
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Cabergoline
  • Epworth Sleepiness Scale
  • Excessive daytime somnolence
  • Parkinson's disease
  • Parkinson's disease Sleep Scale
  • Polysomnography
  • Sleep

ASJC Scopus subject areas

  • Neuroscience(all)

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    Romigi, A., Stanzione, P., Marciani, M. G., Izzi, F., Placidi, F., Cervellino, A., Giacomini, P., Brusa, L., Grossi, K., & Pierantozzi, M. (2006). Effect of cabergoline added to levodopa treatment on sleep-wake cycle in idiopathic Parkinson's disease: An open label 24-hour polysomnographic study. Journal of Neural Transmission, 113(12), 1909-1913. https://doi.org/10.1007/s00702-006-0490-x