Abstract
This study investigated whether canine mesenchymal stromal cells (cMSCs) are able to take up and release paclitaxel (PTX) in active form, and therefore whether they have potential as a tool for therapeutic delivery of this drug. cMSCs from bone marrow and adipose tissue were isolated, expanded and characterised phenotypically. cMSCs were loaded with PTX (cMSCs-PTX) and their capacity for release of PTX was determined by their effect on proliferation of cancer cells. cMSCs-PTX derived from bone marrow and adipose tissue were able to take up and then release active PTX. cMSCs-PTC inhibited proliferation of the canine glioma cell line J3T, and the human glioblastoma cell lines T98G and U87MG. The potential of canine cMSCs-PTX for treatment of canine gliomas should be investigated further.
Original language | English |
---|---|
Pages (from-to) | 41-47 |
Number of pages | 7 |
Journal | Veterinary Journal |
Volume | 223 |
DOIs | |
Publication status | Published - May 1 2017 |
Keywords
- Canine
- Drug delivery
- Glioma
- Mesenchymal stromal cells
- Paclitaxel
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)