Effect of canine mesenchymal stromal cells loaded with paclitaxel on growth of canine glioma and human glioblastoma cell lines

A. Bonomi, E. Ghezzi, L. Pascucci, M. Aralla, V. Ceserani, L. Pettinari, V. Coccè, A. Guercio, G. Alessandri, E. Parati, A. T. Brini, O. Zeira, A. Pessina

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated whether canine mesenchymal stromal cells (cMSCs) are able to take up and release paclitaxel (PTX) in active form, and therefore whether they have potential as a tool for therapeutic delivery of this drug. cMSCs from bone marrow and adipose tissue were isolated, expanded and characterised phenotypically. cMSCs were loaded with PTX (cMSCs-PTX) and their capacity for release of PTX was determined by their effect on proliferation of cancer cells. cMSCs-PTX derived from bone marrow and adipose tissue were able to take up and then release active PTX. cMSCs-PTC inhibited proliferation of the canine glioma cell line J3T, and the human glioblastoma cell lines T98G and U87MG. The potential of canine cMSCs-PTX for treatment of canine gliomas should be investigated further.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalVeterinary Journal
Volume223
DOIs
Publication statusPublished - May 1 2017

Keywords

  • Canine
  • Drug delivery
  • Glioma
  • Mesenchymal stromal cells
  • Paclitaxel

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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