Effect of carbamazepine treatment on EEG changes induced by different cortical activation patterns in newly referred epileptic patients

M. G. Marciani, F. Stefanini, N. Stefani, M. Sabbadini, G. L. Gigli, G. Bernardi

Research output: Contribution to journalArticle

Abstract

Sixteen epileptic patients suffering from focal epilepsy who underwent antiepileptic drug treatment with carbamazepine (CBZ) for the first time were studied. The EEG was recorded at rest with eyes closed, during blocking reaction (BR), fixation (FIX) and mental arithmetic tasks. The computerized EEG study, performed before and after CBZ therapy, utilized spectral analysis. Data underwent statistical evaluation through Anova and correlation analysis. The parameters evaluated were the mean frequency and the mean absolute and relative power. The results have shown that after CBZ treatment there is a decrease in the alpha reactivity during BR and FIX, while a significant increase in beta activity was observed during all tasks. The effect of CBZ therapy on EEG activity during cortical activation patterns are discussed.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalNeuropsychobiology
Volume25
Issue number4
Publication statusPublished - 1992

Keywords

  • Carbamazepine
  • Cognitive tasks
  • EEG

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

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    Marciani, M. G., Stefanini, F., Stefani, N., Sabbadini, M., Gigli, G. L., & Bernardi, G. (1992). Effect of carbamazepine treatment on EEG changes induced by different cortical activation patterns in newly referred epileptic patients. Neuropsychobiology, 25(4), 221-226.