TY - JOUR
T1 - Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis
AU - Verrina, Enrico
AU - Caruso, Ubaldo
AU - Calevo, Maria Grazia
AU - Emma, Francesco
AU - Sorino, Palma
AU - De Palo, Tommaso
AU - Lavoratti, Giancarlo
AU - Dertenois, Laura Turrini
AU - Cassanello, Michela
AU - Cerone, Roberto
AU - Perfumo, Francesco
PY - 2007/5
Y1 - 2007/5
N2 - We prospectively evaluated the effects of L-carnitine supplementation on plasma free carnitine (FC) levels, serum lipid profile, and erythropoietin (rhEPO) requirement in 24 children treated with peritoneal dialysis (PD; n=16) or hemodialysis (HD; n=8). The study was divided into a 3-month observation period, and a 3-month treatment period during which patients received 20 mg/kg per day of L-carnitine given orally. Clinical, biochemical, and hematological data were collected every 3 months. FC levels were measured in plasma and peritoneal dialysate by tandem mass spectrometry. There were no statistically significant changes in lipid levels, hemoglobin, or rhEPO requirements during the course of the study. Fifteen patients (13 PD, 2 HD) had plasma FC levels measured before and after treatment; FC levels increased from 32.1±14.1 μmol/l to 80.9±38.7 μmol/l P
AB - We prospectively evaluated the effects of L-carnitine supplementation on plasma free carnitine (FC) levels, serum lipid profile, and erythropoietin (rhEPO) requirement in 24 children treated with peritoneal dialysis (PD; n=16) or hemodialysis (HD; n=8). The study was divided into a 3-month observation period, and a 3-month treatment period during which patients received 20 mg/kg per day of L-carnitine given orally. Clinical, biochemical, and hematological data were collected every 3 months. FC levels were measured in plasma and peritoneal dialysate by tandem mass spectrometry. There were no statistically significant changes in lipid levels, hemoglobin, or rhEPO requirements during the course of the study. Fifteen patients (13 PD, 2 HD) had plasma FC levels measured before and after treatment; FC levels increased from 32.1±14.1 μmol/l to 80.9±38.7 μmol/l P
KW - Anemia
KW - Dyslipidemia
KW - Erythropoietin
KW - Hemodialysis
KW - L-carnitine
KW - Peritoneal dialysis
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U2 - 10.1007/s00467-006-0408-8
DO - 10.1007/s00467-006-0408-8
M3 - Article
C2 - 17277954
AN - SCOPUS:34247844351
VL - 22
SP - 727
EP - 733
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 5
ER -