Abstract
We prospectively evaluated the effects of L-carnitine supplementation on plasma free carnitine (FC) levels, serum lipid profile, and erythropoietin (rhEPO) requirement in 24 children treated with peritoneal dialysis (PD; n=16) or hemodialysis (HD; n=8). The study was divided into a 3-month observation period, and a 3-month treatment period during which patients received 20 mg/kg per day of L-carnitine given orally. Clinical, biochemical, and hematological data were collected every 3 months. FC levels were measured in plasma and peritoneal dialysate by tandem mass spectrometry. There were no statistically significant changes in lipid levels, hemoglobin, or rhEPO requirements during the course of the study. Fifteen patients (13 PD, 2 HD) had plasma FC levels measured before and after treatment; FC levels increased from 32.1±14.1 μmol/l to 80.9±38.7 μmol/l P
| Original language | English |
|---|---|
| Pages (from-to) | 727-733 |
| Number of pages | 7 |
| Journal | Pediatric Nephrology |
| Volume | 22 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2007 |
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Keywords
- Anemia
- Dyslipidemia
- Erythropoietin
- Hemodialysis
- L-carnitine
- Peritoneal dialysis
ASJC Scopus subject areas
- Nephrology
- Pediatrics, Perinatology, and Child Health
Cite this
Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis. / Verrina, Enrico; Caruso, Ubaldo; Calevo, Maria Grazia; Emma, Francesco; Sorino, Palma; De Palo, Tommaso; Lavoratti, Giancarlo; Dertenois, Laura Turrini; Cassanello, Michela; Cerone, Roberto; Perfumo, Francesco.
In: Pediatric Nephrology, Vol. 22, No. 5, 05.2007, p. 727-733.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis
AU - Verrina, Enrico
AU - Caruso, Ubaldo
AU - Calevo, Maria Grazia
AU - Emma, Francesco
AU - Sorino, Palma
AU - De Palo, Tommaso
AU - Lavoratti, Giancarlo
AU - Dertenois, Laura Turrini
AU - Cassanello, Michela
AU - Cerone, Roberto
AU - Perfumo, Francesco
PY - 2007/5
Y1 - 2007/5
N2 - We prospectively evaluated the effects of L-carnitine supplementation on plasma free carnitine (FC) levels, serum lipid profile, and erythropoietin (rhEPO) requirement in 24 children treated with peritoneal dialysis (PD; n=16) or hemodialysis (HD; n=8). The study was divided into a 3-month observation period, and a 3-month treatment period during which patients received 20 mg/kg per day of L-carnitine given orally. Clinical, biochemical, and hematological data were collected every 3 months. FC levels were measured in plasma and peritoneal dialysate by tandem mass spectrometry. There were no statistically significant changes in lipid levels, hemoglobin, or rhEPO requirements during the course of the study. Fifteen patients (13 PD, 2 HD) had plasma FC levels measured before and after treatment; FC levels increased from 32.1±14.1 μmol/l to 80.9±38.7 μmol/l P
AB - We prospectively evaluated the effects of L-carnitine supplementation on plasma free carnitine (FC) levels, serum lipid profile, and erythropoietin (rhEPO) requirement in 24 children treated with peritoneal dialysis (PD; n=16) or hemodialysis (HD; n=8). The study was divided into a 3-month observation period, and a 3-month treatment period during which patients received 20 mg/kg per day of L-carnitine given orally. Clinical, biochemical, and hematological data were collected every 3 months. FC levels were measured in plasma and peritoneal dialysate by tandem mass spectrometry. There were no statistically significant changes in lipid levels, hemoglobin, or rhEPO requirements during the course of the study. Fifteen patients (13 PD, 2 HD) had plasma FC levels measured before and after treatment; FC levels increased from 32.1±14.1 μmol/l to 80.9±38.7 μmol/l P
KW - Anemia
KW - Dyslipidemia
KW - Erythropoietin
KW - Hemodialysis
KW - L-carnitine
KW - Peritoneal dialysis
UR - http://www.scopus.com/inward/record.url?scp=34247844351&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247844351&partnerID=8YFLogxK
U2 - 10.1007/s00467-006-0408-8
DO - 10.1007/s00467-006-0408-8
M3 - Article
C2 - 17277954
AN - SCOPUS:34247844351
VL - 22
SP - 727
EP - 733
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 5
ER -