Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis

Enrico Verrina, Ubaldo Caruso, Maria Grazia Calevo, Francesco Emma, Palma Sorino, Tommaso De Palo, Giancarlo Lavoratti, Laura Turrini Dertenois, Michela Cassanello, Roberto Cerone, Francesco Perfumo

Research output: Contribution to journalArticlepeer-review

Abstract

We prospectively evaluated the effects of L-carnitine supplementation on plasma free carnitine (FC) levels, serum lipid profile, and erythropoietin (rhEPO) requirement in 24 children treated with peritoneal dialysis (PD; n=16) or hemodialysis (HD; n=8). The study was divided into a 3-month observation period, and a 3-month treatment period during which patients received 20 mg/kg per day of L-carnitine given orally. Clinical, biochemical, and hematological data were collected every 3 months. FC levels were measured in plasma and peritoneal dialysate by tandem mass spectrometry. There were no statistically significant changes in lipid levels, hemoglobin, or rhEPO requirements during the course of the study. Fifteen patients (13 PD, 2 HD) had plasma FC levels measured before and after treatment; FC levels increased from 32.1±14.1 μmol/l to 80.9±38.7 μmol/l P

Original languageEnglish
Pages (from-to)727-733
Number of pages7
JournalPediatric Nephrology
Volume22
Issue number5
DOIs
Publication statusPublished - May 2007

Keywords

  • Anemia
  • Dyslipidemia
  • Erythropoietin
  • Hemodialysis
  • L-carnitine
  • Peritoneal dialysis

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis'. Together they form a unique fingerprint.

Cite this