Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis

Enrico Verrina, Ubaldo Caruso, Maria Grazia Calevo, Francesco Emma, Palma Sorino, Tommaso De Palo, Giancarlo Lavoratti, Laura Turrini Dertenois, Michela Cassanello, Roberto Cerone, Francesco Perfumo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We prospectively evaluated the effects of L-carnitine supplementation on plasma free carnitine (FC) levels, serum lipid profile, and erythropoietin (rhEPO) requirement in 24 children treated with peritoneal dialysis (PD; n=16) or hemodialysis (HD; n=8). The study was divided into a 3-month observation period, and a 3-month treatment period during which patients received 20 mg/kg per day of L-carnitine given orally. Clinical, biochemical, and hematological data were collected every 3 months. FC levels were measured in plasma and peritoneal dialysate by tandem mass spectrometry. There were no statistically significant changes in lipid levels, hemoglobin, or rhEPO requirements during the course of the study. Fifteen patients (13 PD, 2 HD) had plasma FC levels measured before and after treatment; FC levels increased from 32.1±14.1 μmol/l to 80.9±38.7 μmol/l P

Original languageEnglish
Pages (from-to)727-733
Number of pages7
JournalPediatric Nephrology
Volume22
Issue number5
DOIs
Publication statusPublished - May 2007

Fingerprint

Carnitine
Anemia
Dialysis
Lipids
Dialysis Solutions
Peritoneal Dialysis
Erythropoietin
Tandem Mass Spectrometry
Renal Dialysis
Hemoglobins
Observation
Therapeutics
Serum

Keywords

  • Anemia
  • Dyslipidemia
  • Erythropoietin
  • Hemodialysis
  • L-carnitine
  • Peritoneal dialysis

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis. / Verrina, Enrico; Caruso, Ubaldo; Calevo, Maria Grazia; Emma, Francesco; Sorino, Palma; De Palo, Tommaso; Lavoratti, Giancarlo; Dertenois, Laura Turrini; Cassanello, Michela; Cerone, Roberto; Perfumo, Francesco.

In: Pediatric Nephrology, Vol. 22, No. 5, 05.2007, p. 727-733.

Research output: Contribution to journalArticle

Verrina, Enrico ; Caruso, Ubaldo ; Calevo, Maria Grazia ; Emma, Francesco ; Sorino, Palma ; De Palo, Tommaso ; Lavoratti, Giancarlo ; Dertenois, Laura Turrini ; Cassanello, Michela ; Cerone, Roberto ; Perfumo, Francesco. / Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis. In: Pediatric Nephrology. 2007 ; Vol. 22, No. 5. pp. 727-733.
@article{031fb9fb72bd489580cac0fc0403f227,
title = "Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis",
abstract = "We prospectively evaluated the effects of L-carnitine supplementation on plasma free carnitine (FC) levels, serum lipid profile, and erythropoietin (rhEPO) requirement in 24 children treated with peritoneal dialysis (PD; n=16) or hemodialysis (HD; n=8). The study was divided into a 3-month observation period, and a 3-month treatment period during which patients received 20 mg/kg per day of L-carnitine given orally. Clinical, biochemical, and hematological data were collected every 3 months. FC levels were measured in plasma and peritoneal dialysate by tandem mass spectrometry. There were no statistically significant changes in lipid levels, hemoglobin, or rhEPO requirements during the course of the study. Fifteen patients (13 PD, 2 HD) had plasma FC levels measured before and after treatment; FC levels increased from 32.1±14.1 μmol/l to 80.9±38.7 μmol/l P",
keywords = "Anemia, Dyslipidemia, Erythropoietin, Hemodialysis, L-carnitine, Peritoneal dialysis",
author = "Enrico Verrina and Ubaldo Caruso and Calevo, {Maria Grazia} and Francesco Emma and Palma Sorino and {De Palo}, Tommaso and Giancarlo Lavoratti and Dertenois, {Laura Turrini} and Michela Cassanello and Roberto Cerone and Francesco Perfumo",
year = "2007",
month = "5",
doi = "10.1007/s00467-006-0408-8",
language = "English",
volume = "22",
pages = "727--733",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis

AU - Verrina, Enrico

AU - Caruso, Ubaldo

AU - Calevo, Maria Grazia

AU - Emma, Francesco

AU - Sorino, Palma

AU - De Palo, Tommaso

AU - Lavoratti, Giancarlo

AU - Dertenois, Laura Turrini

AU - Cassanello, Michela

AU - Cerone, Roberto

AU - Perfumo, Francesco

PY - 2007/5

Y1 - 2007/5

N2 - We prospectively evaluated the effects of L-carnitine supplementation on plasma free carnitine (FC) levels, serum lipid profile, and erythropoietin (rhEPO) requirement in 24 children treated with peritoneal dialysis (PD; n=16) or hemodialysis (HD; n=8). The study was divided into a 3-month observation period, and a 3-month treatment period during which patients received 20 mg/kg per day of L-carnitine given orally. Clinical, biochemical, and hematological data were collected every 3 months. FC levels were measured in plasma and peritoneal dialysate by tandem mass spectrometry. There were no statistically significant changes in lipid levels, hemoglobin, or rhEPO requirements during the course of the study. Fifteen patients (13 PD, 2 HD) had plasma FC levels measured before and after treatment; FC levels increased from 32.1±14.1 μmol/l to 80.9±38.7 μmol/l P

AB - We prospectively evaluated the effects of L-carnitine supplementation on plasma free carnitine (FC) levels, serum lipid profile, and erythropoietin (rhEPO) requirement in 24 children treated with peritoneal dialysis (PD; n=16) or hemodialysis (HD; n=8). The study was divided into a 3-month observation period, and a 3-month treatment period during which patients received 20 mg/kg per day of L-carnitine given orally. Clinical, biochemical, and hematological data were collected every 3 months. FC levels were measured in plasma and peritoneal dialysate by tandem mass spectrometry. There were no statistically significant changes in lipid levels, hemoglobin, or rhEPO requirements during the course of the study. Fifteen patients (13 PD, 2 HD) had plasma FC levels measured before and after treatment; FC levels increased from 32.1±14.1 μmol/l to 80.9±38.7 μmol/l P

KW - Anemia

KW - Dyslipidemia

KW - Erythropoietin

KW - Hemodialysis

KW - L-carnitine

KW - Peritoneal dialysis

UR - http://www.scopus.com/inward/record.url?scp=34247844351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247844351&partnerID=8YFLogxK

U2 - 10.1007/s00467-006-0408-8

DO - 10.1007/s00467-006-0408-8

M3 - Article

C2 - 17277954

AN - SCOPUS:34247844351

VL - 22

SP - 727

EP - 733

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 5

ER -