TY - JOUR
T1 - Effect of centrally administered atropine and pirenzepine on radial arm maze performance in the rat
AU - Sala, Mariaelvina
AU - Braida, Daniela
AU - Calcaterra, Paola
AU - Primula Leone, Maria
AU - Arianna Comotti, Franca
AU - Gianola, Silvia
AU - Gori, Enzo
PY - 1991/2/26
Y1 - 1991/2/26
N2 - The effect of two anticholinergic drugs administered intracerebroventricularly on acquisition of an 8-arm radial maze task was examined in the rat. Increasing doses of atropine (1, 4.5, 22.5, 45 μg/rat) and pirenzepine (4.5, 15, 60, 90 μg/rat) significantly impaired performance in the working-memory components of the task. For both drugs this impairment was linearly related to the log of the administered doses and log-dose-response relationships were parallel. The regression lines calculated for each parameter for both drugs were parallel to each other, thus allowing us to calculate the potency of atropine versus pirenzepine: atropine was 5.4 times more potent than pirenzepine for correct arm entries, 10 times more potent for the number of errors and 4 times more potent for the total time taken to complete the task. The relevance of M1 and M2 subtype central acetylcholine receptors in cognitive processes is discussed.
AB - The effect of two anticholinergic drugs administered intracerebroventricularly on acquisition of an 8-arm radial maze task was examined in the rat. Increasing doses of atropine (1, 4.5, 22.5, 45 μg/rat) and pirenzepine (4.5, 15, 60, 90 μg/rat) significantly impaired performance in the working-memory components of the task. For both drugs this impairment was linearly related to the log of the administered doses and log-dose-response relationships were parallel. The regression lines calculated for each parameter for both drugs were parallel to each other, thus allowing us to calculate the potency of atropine versus pirenzepine: atropine was 5.4 times more potent than pirenzepine for correct arm entries, 10 times more potent for the number of errors and 4 times more potent for the total time taken to complete the task. The relevance of M1 and M2 subtype central acetylcholine receptors in cognitive processes is discussed.
KW - (Intracerebroventricular administration)
KW - Atropine
KW - Pirenzepine
KW - Radial maze
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U2 - 10.1016/0014-2999(91)90122-7
DO - 10.1016/0014-2999(91)90122-7
M3 - Article
C2 - 2060592
AN - SCOPUS:0026027130
VL - 194
SP - 45
EP - 49
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -