TY - JOUR
T1 - Effect of chemical sympathectomy on the content of acetylcholine, choline and choline acetyltransferase activity in the cat spleen and iris
AU - Consolo, S.
AU - Garattini, S.
AU - Ladinsky, H.
AU - Thoenen, H.
PY - 1972/2/1
Y1 - 1972/2/1
N2 - 1. Acetylcholine and choline were measured in the spleens and irides of normal and 6‐hydroxydopamine‐treated cats. In addition, choline acetyltransferase activity was measured in the spleens. 2. No acetylcholine or choline acetyltransferase activity were found in spleens of normal or treated cats. The choline content of normal spleens was 12·4 ± 1·5 μg/g wet wt. (mean ± S.E. of mean), which was not significantly altered by chemical sympathectomy. 3. The acetylcholine and choline contents of the cat iris were 3·0 ± 0·3 μg/g wet wt. and 7·7 ± 0·9 μg/g wet wt., respectively. There was no difference in acetylcholine and choline concentrations between left and right or normal and sympathectomized irides. 4. These results are discussed in relation to the question of a cholinergic link in post‐ganglionic sympathetic transmission.
AB - 1. Acetylcholine and choline were measured in the spleens and irides of normal and 6‐hydroxydopamine‐treated cats. In addition, choline acetyltransferase activity was measured in the spleens. 2. No acetylcholine or choline acetyltransferase activity were found in spleens of normal or treated cats. The choline content of normal spleens was 12·4 ± 1·5 μg/g wet wt. (mean ± S.E. of mean), which was not significantly altered by chemical sympathectomy. 3. The acetylcholine and choline contents of the cat iris were 3·0 ± 0·3 μg/g wet wt. and 7·7 ± 0·9 μg/g wet wt., respectively. There was no difference in acetylcholine and choline concentrations between left and right or normal and sympathectomized irides. 4. These results are discussed in relation to the question of a cholinergic link in post‐ganglionic sympathetic transmission.
UR - http://www.scopus.com/inward/record.url?scp=0015290205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015290205&partnerID=8YFLogxK
U2 - 10.1113/jphysiol.1972.sp009727
DO - 10.1113/jphysiol.1972.sp009727
M3 - Article
C2 - 4335730
AN - SCOPUS:0015290205
VL - 220
SP - 639
EP - 646
JO - Journal of Physiology
JF - Journal of Physiology
SN - 0022-3751
IS - 3
ER -