Effect of chemotherapeutic agents on natural cell-mediated cytotoxicity in mice

Alberto Mantovani, Walter Luini, Giuseppe Peri, Annunciata Vecchi, Federico Spreafico

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Spleen natural killer (NK) activity was investigated In cells from C57BL/6J mice treated with various chemotherapeutic agents; 51Cr-labeled YAC-1 lymphoma cells were used as targets. Treatment with azathioprlne (a single Injection of 100400 mg/kg Ip or 5 daily doses of 80 mg/kg Ip) and cyclophosphamide (a single Injection of 50-200 mg/kg ip or 5 daily doses of 25 mg/kg Ip) resulted In a marked dose-dependent inhibition of NK activity 2 days later. NK cells recovered rapidly from drug- induced suppression; by 7 days after drug treatment, no difference from control values was observed. Dlmethyltriazenolmida- zole carboxamide (50-200 mg/kg ip) and adriamycin (10-15 mg/kg Iv) did not impair natural cytotoxicity per unit number of lymphoid cells, daunomycln (10 mg/kg Iv) caused borderline Impairment of NK activity, and Af-trifluoroacetyl-adrlamycin-14- valerate (80 mg/kg iv) markedly suppressed natural cytotoxicity. These results are discussed In light of the known effects of these agents on T-cells, B-cells, and K-cells and on hematopoietic histocompatlbility-type reactions.—J Natl Cancer Inst 61: 1255- 1261, 1978.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
JournalJournal of the National Cancer Institute
Issue number5
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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