Effect of chemotherapeutic agents on natural cell-mediated cytotoxicity in mice

Alberto Mantovani, Walter Luini, Giuseppe Peri, Annunciata Vecchi, Federico Spreafico

Research output: Contribution to journalArticle

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Abstract

Spleen natural killer (NK) activity was investigated In cells from C57BL/6J mice treated with various chemotherapeutic agents; 51Cr-labeled YAC-1 lymphoma cells were used as targets. Treatment with azathioprlne (a single Injection of 100400 mg/kg Ip or 5 daily doses of 80 mg/kg Ip) and cyclophosphamide (a single Injection of 50-200 mg/kg ip or 5 daily doses of 25 mg/kg Ip) resulted In a marked dose-dependent inhibition of NK activity 2 days later. NK cells recovered rapidly from drug- induced suppression; by 7 days after drug treatment, no difference from control values was observed. Dlmethyltriazenolmida- zole carboxamide (50-200 mg/kg ip) and adriamycin (10-15 mg/kg Iv) did not impair natural cytotoxicity per unit number of lymphoid cells, daunomycln (10 mg/kg Iv) caused borderline Impairment of NK activity, and Af-trifluoroacetyl-adrlamycin-14- valerate (80 mg/kg iv) markedly suppressed natural cytotoxicity. These results are discussed In light of the known effects of these agents on T-cells, B-cells, and K-cells and on hematopoietic histocompatlbility-type reactions.—J Natl Cancer Inst 61: 1255- 1261, 1978.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
JournalJournal of the National Cancer Institute
Volume61
Issue number5
DOIs
Publication statusPublished - 1978

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Valerates
Injections
Inbred C57BL Mouse
Natural Killer Cells
Pharmaceutical Preparations
Doxorubicin
Cyclophosphamide
Lymphoma
B-Lymphocytes
Spleen
Lymphocytes
T-Lymphocytes
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Effect of chemotherapeutic agents on natural cell-mediated cytotoxicity in mice. / Mantovani, Alberto; Luini, Walter; Peri, Giuseppe; Vecchi, Annunciata; Spreafico, Federico.

In: Journal of the National Cancer Institute, Vol. 61, No. 5, 1978, p. 1255-1261.

Research output: Contribution to journalArticle

Mantovani, Alberto ; Luini, Walter ; Peri, Giuseppe ; Vecchi, Annunciata ; Spreafico, Federico. / Effect of chemotherapeutic agents on natural cell-mediated cytotoxicity in mice. In: Journal of the National Cancer Institute. 1978 ; Vol. 61, No. 5. pp. 1255-1261.
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