Spleen natural killer (NK) activity was investigated In cells from C57BL/6J mice treated with various chemotherapeutic agents; 51Cr-labeled YAC-1 lymphoma cells were used as targets. Treatment with azathioprlne (a single Injection of 100400 mg/kg Ip or 5 daily doses of 80 mg/kg Ip) and cyclophosphamide (a single Injection of 50-200 mg/kg ip or 5 daily doses of 25 mg/kg Ip) resulted In a marked dose-dependent inhibition of NK activity 2 days later. NK cells recovered rapidly from drug- induced suppression; by 7 days after drug treatment, no difference from control values was observed. Dlmethyltriazenolmida- zole carboxamide (50-200 mg/kg ip) and adriamycin (10-15 mg/kg Iv) did not impair natural cytotoxicity per unit number of lymphoid cells, daunomycln (10 mg/kg Iv) caused borderline Impairment of NK activity, and Af-trifluoroacetyl-adrlamycin-14- valerate (80 mg/kg iv) markedly suppressed natural cytotoxicity. These results are discussed In light of the known effects of these agents on T-cells, B-cells, and K-cells and on hematopoietic histocompatlbility-type reactions.—J Natl Cancer Inst 61: 1255- 1261, 1978.
ASJC Scopus subject areas
- Cancer Research