Effect of chemotherapy with 5-fluorouracil on intestinal permeability and absorption in patients with advanced colorectal cancer

Bruno Daniele, Mario Secondulfo, Rocco De Vivo, Sandro Pignata, Laura De Magistris, Paolo Delrio, Raffaele Palaia, Emiddio Barletta, Rosa Tambaro, Romano Carratù

Research output: Contribution to journalArticlepeer-review

Abstract

5-Fluorouracil (5-FU), in association with leucovorin (LV), is the most used chemotherapy agent in the treatment of colorectal cancer. Response rate, as well as side-effect incidence, increases with the dose intensity of regimens that are used. The most common dose-limiting toxicity for 5-FU/LV modulation is diarrhea. To assess the modification of small intestinal function, we investigated the changes in intestinal permeability (IP) and intestinal absorption (IA) in 41 chemo-naive patients (21 men and 22 women; mean age, 61 ± 9 years) with advanced colorectal cancer after treatment with the association of folinic acid and 5-FU. After chemotherapy administration, we found a marked increase in IP and a reduction in IA, measured as cellobiose-mannitol (CE-MA) ratio (p <0.0001) and D-xylose absorption (p = 0.0001), respectively. Patients who experienced diarrhea have an increase in CE-MA ratio and a reduction in D-xylose absorption values, both statistically significant. Cellobiose-mannitol ratio and D-xylose absorption tests can be used for the assessment of toxic effect of 5-FU on mature intestinal epithelium and also for evaluating the role of cytoprotective agents.

Original languageEnglish
Pages (from-to)228-230
Number of pages3
JournalJournal of Clinical Gastroenterology
Volume32
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • 5-Fluorouracil
  • Colorectal cancer
  • Intestinal absorption
  • Intestinal permeability

ASJC Scopus subject areas

  • Gastroenterology

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