Abstract
Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [3H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 187-192 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 40 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Sep 30 1983 |
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Keywords
- adenylate cyclase
- chronic ethanol
- dopaminergic receptors
- GTP
- rat
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum. / Lucchi, Laura; Covelli, Vito; Anthopoulou, Helene; Franco Spano, Pier; Trabucchi, Marco.
In: Neuroscience Letters, Vol. 40, No. 2, 30.09.1983, p. 187-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum
AU - Lucchi, Laura
AU - Covelli, Vito
AU - Anthopoulou, Helene
AU - Franco Spano, Pier
AU - Trabucchi, Marco
PY - 1983/9/30
Y1 - 1983/9/30
N2 - Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [3H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.
AB - Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [3H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.
KW - adenylate cyclase
KW - chronic ethanol
KW - dopaminergic receptors
KW - GTP
KW - rat
UR - http://www.scopus.com/inward/record.url?scp=0020590770&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020590770&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(83)90300-2
DO - 10.1016/0304-3940(83)90300-2
M3 - Article
VL - 40
SP - 187
EP - 192
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -