Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum

Laura Lucchi, Vito Covelli, Helene Anthopoulou, Pier Franco Spano, Marco Trabucchi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [3H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalNeuroscience Letters
Volume40
Issue number2
DOIs
Publication statusPublished - Sep 30 1983

Fingerprint

Adenylyl Cyclases
Ethanol
Corpus Striatum
Spiperone
Membranes
Apomorphine
Dopamine Agonists
Guanosine Triphosphate
Cyclic AMP
Dopamine

Keywords

  • adenylate cyclase
  • chronic ethanol
  • dopaminergic receptors
  • GTP
  • rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lucchi, L., Covelli, V., Anthopoulou, H., Franco Spano, P., & Trabucchi, M. (1983). Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum. Neuroscience Letters, 40(2), 187-192. https://doi.org/10.1016/0304-3940(83)90300-2

Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum. / Lucchi, Laura; Covelli, Vito; Anthopoulou, Helene; Franco Spano, Pier; Trabucchi, Marco.

In: Neuroscience Letters, Vol. 40, No. 2, 30.09.1983, p. 187-192.

Research output: Contribution to journalArticle

Lucchi, L, Covelli, V, Anthopoulou, H, Franco Spano, P & Trabucchi, M 1983, 'Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum', Neuroscience Letters, vol. 40, no. 2, pp. 187-192. https://doi.org/10.1016/0304-3940(83)90300-2
Lucchi, Laura ; Covelli, Vito ; Anthopoulou, Helene ; Franco Spano, Pier ; Trabucchi, Marco. / Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum. In: Neuroscience Letters. 1983 ; Vol. 40, No. 2. pp. 187-192.
@article{7050d76391b242f2b90175243a1c2523,
title = "Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum",
abstract = "Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [3H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.",
keywords = "adenylate cyclase, chronic ethanol, dopaminergic receptors, GTP, rat",
author = "Laura Lucchi and Vito Covelli and Helene Anthopoulou and {Franco Spano}, Pier and Marco Trabucchi",
year = "1983",
month = "9",
day = "30",
doi = "10.1016/0304-3940(83)90300-2",
language = "English",
volume = "40",
pages = "187--192",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum

AU - Lucchi, Laura

AU - Covelli, Vito

AU - Anthopoulou, Helene

AU - Franco Spano, Pier

AU - Trabucchi, Marco

PY - 1983/9/30

Y1 - 1983/9/30

N2 - Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [3H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.

AB - Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [3H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.

KW - adenylate cyclase

KW - chronic ethanol

KW - dopaminergic receptors

KW - GTP

KW - rat

UR - http://www.scopus.com/inward/record.url?scp=0020590770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020590770&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(83)90300-2

DO - 10.1016/0304-3940(83)90300-2

M3 - Article

VL - 40

SP - 187

EP - 192

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -