Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum

Laura Lucchi; Vito Covelli; Helene Anthopoulou; Pier Franco Spano; Marco Trabucchi

doi:10.1016/0304-3940(83)90300-2

Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum

Laura Lucchi, Vito Covelli, Helene Anthopoulou, Pier Franco Spano, Marco Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [³H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.

Original language	English
Pages (from-to)	187-192
Number of pages	6
Journal	Neuroscience Letters
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(83)90300-2
Publication status	Published - Sep 30 1983

Keywords

adenylate cyclase
chronic ethanol
dopaminergic receptors
GTP
rat

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(83)90300-2

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title = "Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum",

abstract = "Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [3H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.",

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author = "Laura Lucchi and Vito Covelli and Helene Anthopoulou and {Franco Spano}, Pier and Marco Trabucchi",

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doi = "10.1016/0304-3940(83)90300-2",

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T1 - Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum

AU - Lucchi, Laura

AU - Covelli, Vito

AU - Anthopoulou, Helene

AU - Franco Spano, Pier

AU - Trabucchi, Marco

PY - 1983/9/30

Y1 - 1983/9/30

N2 - Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [3H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.

AB - Chronic ethanol consumption induces an increase in striatal adenylate cyclase enzymatic activity but is unable to further potentiate the dopamine stimulated production of cyclic-AMP. In striatal membranes obtained from chronic ethanol-treated rats, apomorphine exerts a more potent inhibition of [3H]spiperone binding when compared with controls, demonstrating that ethanol increases the affinity of the dopaminergic receptors associated with adenylate cyclase activity. In addition, GTP is unable to modify the agonist component of dopamine receptor in membrane exposed 'in vivo' to ethanol. Data are discussed in terms of a derangement of receptor-adenylate cyclase coupling system produced by chronic ethanol treatment.

KW - adenylate cyclase

KW - chronic ethanol

KW - dopaminergic receptors

KW - GTP

KW - rat

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Effect of chronic ethanol treatment on adenylate cyclase activity in rat striatum

Abstract

Keywords

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