Abstract
The effect of chronic lead treatment on brain γ-amino-butyric acid (GABA)ergic function was studied in an attempt to correlate the clinical aspects of chronic exposure to the metal with specific neurochemical alterations. [3H]GABA-specific binding and cyclic guanosine monophosphate (GMP) content were measured in various rat brain areas and were found to be increased in the cerebellum and decreased in the striatum of rats after chronic lead treatment. The changes found in the GABA-ergic neurons were correlated with the different levels of lead exposure in rats. Our results indicated that lead selectively affects GABA-ergic function in various rat brain areas, inducing effects which are dose-dependent.
| Original language | English |
|---|---|
| Pages (from-to) | 427-432 |
| Number of pages | 6 |
| Journal | Toxicology Letters |
| Volume | 6 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1980 |
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ASJC Scopus subject areas
- Toxicology
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Effect of chronic lead treatment on GABA-ergic receptor function in rat brain. / Memo, M.; Lucchi, L.; Spano, P. F.; Trabucchi, M.
In: Toxicology Letters, Vol. 6, No. 6, 1980, p. 427-432.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of chronic lead treatment on GABA-ergic receptor function in rat brain
AU - Memo, M.
AU - Lucchi, L.
AU - Spano, P. F.
AU - Trabucchi, M.
PY - 1980
Y1 - 1980
N2 - The effect of chronic lead treatment on brain γ-amino-butyric acid (GABA)ergic function was studied in an attempt to correlate the clinical aspects of chronic exposure to the metal with specific neurochemical alterations. [3H]GABA-specific binding and cyclic guanosine monophosphate (GMP) content were measured in various rat brain areas and were found to be increased in the cerebellum and decreased in the striatum of rats after chronic lead treatment. The changes found in the GABA-ergic neurons were correlated with the different levels of lead exposure in rats. Our results indicated that lead selectively affects GABA-ergic function in various rat brain areas, inducing effects which are dose-dependent.
AB - The effect of chronic lead treatment on brain γ-amino-butyric acid (GABA)ergic function was studied in an attempt to correlate the clinical aspects of chronic exposure to the metal with specific neurochemical alterations. [3H]GABA-specific binding and cyclic guanosine monophosphate (GMP) content were measured in various rat brain areas and were found to be increased in the cerebellum and decreased in the striatum of rats after chronic lead treatment. The changes found in the GABA-ergic neurons were correlated with the different levels of lead exposure in rats. Our results indicated that lead selectively affects GABA-ergic function in various rat brain areas, inducing effects which are dose-dependent.
UR - http://www.scopus.com/inward/record.url?scp=0019196134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019196134&partnerID=8YFLogxK
U2 - 10.1016/0378-4274(80)90118-6
DO - 10.1016/0378-4274(80)90118-6
M3 - Article
C2 - 6255631
AN - SCOPUS:0019196134
VL - 6
SP - 427
EP - 432
JO - Toxicology Letters
JF - Toxicology Letters
SN - 0378-4274
IS - 6
ER -