Effect of chronic lead treatment on GABA-ergic receptor function in rat brain

M. Memo, L. Lucchi, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The effect of chronic lead treatment on brain γ-amino-butyric acid (GABA)ergic function was studied in an attempt to correlate the clinical aspects of chronic exposure to the metal with specific neurochemical alterations. [3H]GABA-specific binding and cyclic guanosine monophosphate (GMP) content were measured in various rat brain areas and were found to be increased in the cerebellum and decreased in the striatum of rats after chronic lead treatment. The changes found in the GABA-ergic neurons were correlated with the different levels of lead exposure in rats. Our results indicated that lead selectively affects GABA-ergic function in various rat brain areas, inducing effects which are dose-dependent.

Original languageEnglish
Pages (from-to)427-432
Number of pages6
JournalToxicology Letters
Volume6
Issue number6
DOIs
Publication statusPublished - 1980

Fingerprint

GABA Receptors
gamma-Aminobutyric Acid
Rats
Brain
GABAergic Neurons
Butyric Acid
Cyclic GMP
Cerebellum
Neurons
Metals
Lead

ASJC Scopus subject areas

  • Toxicology

Cite this

Effect of chronic lead treatment on GABA-ergic receptor function in rat brain. / Memo, M.; Lucchi, L.; Spano, P. F.; Trabucchi, M.

In: Toxicology Letters, Vol. 6, No. 6, 1980, p. 427-432.

Research output: Contribution to journalArticle

Memo, M. ; Lucchi, L. ; Spano, P. F. ; Trabucchi, M. / Effect of chronic lead treatment on GABA-ergic receptor function in rat brain. In: Toxicology Letters. 1980 ; Vol. 6, No. 6. pp. 427-432.
@article{9832f7819d784a0fad4e3aa9e0624da2,
title = "Effect of chronic lead treatment on GABA-ergic receptor function in rat brain",
abstract = "The effect of chronic lead treatment on brain γ-amino-butyric acid (GABA)ergic function was studied in an attempt to correlate the clinical aspects of chronic exposure to the metal with specific neurochemical alterations. [3H]GABA-specific binding and cyclic guanosine monophosphate (GMP) content were measured in various rat brain areas and were found to be increased in the cerebellum and decreased in the striatum of rats after chronic lead treatment. The changes found in the GABA-ergic neurons were correlated with the different levels of lead exposure in rats. Our results indicated that lead selectively affects GABA-ergic function in various rat brain areas, inducing effects which are dose-dependent.",
author = "M. Memo and L. Lucchi and Spano, {P. F.} and M. Trabucchi",
year = "1980",
doi = "10.1016/0378-4274(80)90118-6",
language = "English",
volume = "6",
pages = "427--432",
journal = "Toxicology Letters",
issn = "0378-4274",
publisher = "Elsevier BV",
number = "6",

}

TY - JOUR

T1 - Effect of chronic lead treatment on GABA-ergic receptor function in rat brain

AU - Memo, M.

AU - Lucchi, L.

AU - Spano, P. F.

AU - Trabucchi, M.

PY - 1980

Y1 - 1980

N2 - The effect of chronic lead treatment on brain γ-amino-butyric acid (GABA)ergic function was studied in an attempt to correlate the clinical aspects of chronic exposure to the metal with specific neurochemical alterations. [3H]GABA-specific binding and cyclic guanosine monophosphate (GMP) content were measured in various rat brain areas and were found to be increased in the cerebellum and decreased in the striatum of rats after chronic lead treatment. The changes found in the GABA-ergic neurons were correlated with the different levels of lead exposure in rats. Our results indicated that lead selectively affects GABA-ergic function in various rat brain areas, inducing effects which are dose-dependent.

AB - The effect of chronic lead treatment on brain γ-amino-butyric acid (GABA)ergic function was studied in an attempt to correlate the clinical aspects of chronic exposure to the metal with specific neurochemical alterations. [3H]GABA-specific binding and cyclic guanosine monophosphate (GMP) content were measured in various rat brain areas and were found to be increased in the cerebellum and decreased in the striatum of rats after chronic lead treatment. The changes found in the GABA-ergic neurons were correlated with the different levels of lead exposure in rats. Our results indicated that lead selectively affects GABA-ergic function in various rat brain areas, inducing effects which are dose-dependent.

UR - http://www.scopus.com/inward/record.url?scp=0019196134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019196134&partnerID=8YFLogxK

U2 - 10.1016/0378-4274(80)90118-6

DO - 10.1016/0378-4274(80)90118-6

M3 - Article

C2 - 6255631

AN - SCOPUS:0019196134

VL - 6

SP - 427

EP - 432

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

IS - 6

ER -