Effect of chronic treatment with β-blockers on resting energy expenditure in obese hypertensive patients during a low-calorie and physical training program

L. A. Gondoni, M. A. Tagliaferri, A. M. Titon, F. Nibbio, A. Liuzzi, G. Leonetti

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Aim: To evaluate whether chronic treatment with β-blockers influences resting energy expenditure (REE) and weight loss after a period of diet and physical activity in obese hypertensive patients. Methods and Results: Seventy-eight obese hypertensive patients (24 males and 54 females) aged 53.7±11.1 years with mean BMI of 42.4±5.8 kg/m 2 were enrolled. Thirty-eight patients were using β-blockers while 40 patients who had not received β-blockers in the past 6 months were the control group. REE was measured with indirect calorimetric method. Total body fat mass, total body fat-free mass (FFM) and total body water (W) were determined by bioelectrical impedance analysis. Patients and controls underwent a structured physical training program and a hypocaloric diet for a period of 31.6±10.6 days. Measured REE in patients taking β-blockers was 1818±309 kcal/24 h and 1853±348 kcal/24 h in patients not taking β-blockers; p=non significant. Weight and BMI loss were similar between the two groups and were respectively -6.43±2.62 kg and -2.42±0.91 kg/m2 in the β-blocker group and -7.49±3.10 kg, -2.78±1.03 kg/m2 in the non β-blocker group. Body composition was similar in the two groups. In the comparison between patients treated with selective β 1-adrenoceptors blockers and non selective β-blockers we found a significant difference in REE (1704±283 vs 1974±278; p=0.012) and in weight loss (-5.6 ±2.4 vs - 7.5±2.7; p=0.048) at the end of study. Conclusions: Beta-blockers are not associated with a lower REE in obese subjects compared to other antihypertensive treatment. Use of non selective β-adrenergic blockers is associated with a higher REE and weight loss compared to use of selective β 1-adrenergic blockers. Non selective β-blockers could be indicated among first choice drugs in hypertensive severely obese subjects without contraindications to β-blockade. Nutr Metab Cardiovasc Dis (2003) 13: 232-237

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume13
Issue number4
DOIs
Publication statusPublished - Aug 2003

Keywords

  • β-blockers
  • Hypertension
  • Obesity
  • Resting energy expenditure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine (miscellaneous)
  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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