Effetto del trattamento cronico con Gabapentin sul sonno notturno

Translated title of the contribution: Effect of chronic treatment with Gabapentin on nocturnal sleep

F. Placidi, M. Diomedi, A. Scalise, G. Silvestri, M. G. Marciani, G. L. Gigli

Research output: Contribution to journalArticlepeer-review


Similar to other antiepileptic drugs (AEDs), little is known about the effects of Gabapentin (GBP) on nocturnal sleep, despite the strict relationship between sleep and epileptic discharges. We studied nocturnal sleep in 8 patients undergoing add-on therapy with GBP for seizures refractory to common AEDs. GBP caused a significant increase of REM sleep and a significant reduction of number of awakenings. Since REM sleep and epileptic discharges are antagonist in the large majority of patients, the improved stability of nocturnal sleep could have played an important role in the anticonvulsant effect of GBP.

Translated title of the contributionEffect of chronic treatment with Gabapentin on nocturnal sleep
Original languageItalian
Pages (from-to)81-82
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number99
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Clinical Neurology


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