Effetto del trattamento cronico con Gabapentin sul sonno notturno

F. Placidi; M. Diomedi; A. Scalise; G. Silvestri; M. G. Marciani; G. L. Gigli

Effetto del trattamento cronico con Gabapentin sul sonno notturno

Translated title of the contribution: Effect of chronic treatment with Gabapentin on nocturnal sleep

F. Placidi, M. Diomedi, A. Scalise, G. Silvestri, M. G. Marciani, G. L. Gigli

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Similar to other antiepileptic drugs (AEDs), little is known about the effects of Gabapentin (GBP) on nocturnal sleep, despite the strict relationship between sleep and epileptic discharges. We studied nocturnal sleep in 8 patients undergoing add-on therapy with GBP for seizures refractory to common AEDs. GBP caused a significant increase of REM sleep and a significant reduction of number of awakenings. Since REM sleep and epileptic discharges are antagonist in the large majority of patients, the improved stability of nocturnal sleep could have played an important role in the anticonvulsant effect of GBP.

Translated title of the contribution	Effect of chronic treatment with Gabapentin on nocturnal sleep
Original language	Italian
Pages (from-to)	81-82
Number of pages	2
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	99
Publication status	Published - 1997

ASJC Scopus subject areas

Clinical Neurology

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Cite this

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title = "Effetto del trattamento cronico con Gabapentin sul sonno notturno",

abstract = "Similar to other antiepileptic drugs (AEDs), little is known about the effects of Gabapentin (GBP) on nocturnal sleep, despite the strict relationship between sleep and epileptic discharges. We studied nocturnal sleep in 8 patients undergoing add-on therapy with GBP for seizures refractory to common AEDs. GBP caused a significant increase of REM sleep and a significant reduction of number of awakenings. Since REM sleep and epileptic discharges are antagonist in the large majority of patients, the improved stability of nocturnal sleep could have played an important role in the anticonvulsant effect of GBP.",

keywords = "Epilepsy, Gabapentin, Sleep",

author = "F. Placidi and M. Diomedi and A. Scalise and G. Silvestri and Marciani, {M. G.} and Gigli, {G. L.}",

year = "1997",

language = "Italian",

pages = "81--82",

journal = "Bollettino - Lega Italiana contro l'Epilessia",

issn = "0394-560X",

publisher = "Lega Italiana contro l'Epilessia",

number = "99",

}

TY - JOUR

T1 - Effetto del trattamento cronico con Gabapentin sul sonno notturno

AU - Placidi, F.

AU - Diomedi, M.

AU - Scalise, A.

AU - Silvestri, G.

AU - Marciani, M. G.

AU - Gigli, G. L.

PY - 1997

Y1 - 1997

N2 - Similar to other antiepileptic drugs (AEDs), little is known about the effects of Gabapentin (GBP) on nocturnal sleep, despite the strict relationship between sleep and epileptic discharges. We studied nocturnal sleep in 8 patients undergoing add-on therapy with GBP for seizures refractory to common AEDs. GBP caused a significant increase of REM sleep and a significant reduction of number of awakenings. Since REM sleep and epileptic discharges are antagonist in the large majority of patients, the improved stability of nocturnal sleep could have played an important role in the anticonvulsant effect of GBP.

AB - Similar to other antiepileptic drugs (AEDs), little is known about the effects of Gabapentin (GBP) on nocturnal sleep, despite the strict relationship between sleep and epileptic discharges. We studied nocturnal sleep in 8 patients undergoing add-on therapy with GBP for seizures refractory to common AEDs. GBP caused a significant increase of REM sleep and a significant reduction of number of awakenings. Since REM sleep and epileptic discharges are antagonist in the large majority of patients, the improved stability of nocturnal sleep could have played an important role in the anticonvulsant effect of GBP.

KW - Epilepsy

KW - Gabapentin

KW - Sleep

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M3 - Articolo

AN - SCOPUS:0031420655

SP - 81

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JO - Bollettino - Lega Italiana contro l'Epilessia

JF - Bollettino - Lega Italiana contro l'Epilessia

SN - 0394-560X

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