Similar to other antiepileptic drugs (AEDs), little is known about the effects of Gabapentin (GBP) on nocturnal sleep, despite the strict relationship between sleep and epileptic discharges. We studied nocturnal sleep in 8 patients undergoing add-on therapy with GBP for seizures refractory to common AEDs. GBP caused a significant increase of REM sleep and a significant reduction of number of awakenings. Since REM sleep and epileptic discharges are antagonist in the large majority of patients, the improved stability of nocturnal sleep could have played an important role in the anticonvulsant effect of GBP.
|Translated title of the contribution||Effect of chronic treatment with Gabapentin on nocturnal sleep|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology