Abstract
Octreotide nasal powder is a delivery system of the somatostatin analogue developed to overcome the inconvenience of repeated subcutaneous administrations. Eight patients with clinically active acromegaly were treated for three months with octreotide nasal powder which was administered at the initial dosage of 0.125 mg tid, doubling the dosage up to 2 mg tid in order to obtain a mean GH value below 5 μg/l during 8 daytime hours. In 4 of these patients, treatment was prolonged till the sixth month. Blood samples were taken on days 15, 29, 43, 55, 90, 120, 150, 180 for GH, IGF-1, IGFBP-3, IGFBP-1 and insulin measurements. Before treatment, mean daytime GH and morning IGF-1 serum levels were both increased but not correlated with each other. Serum IGFBP-3 levels were higher than normal and positively correlated with those of GH, IGF-1 and insulin, Insulin levels were elevated and positively correlated with those of GH but not with those of IGF-1 and IGFBP-1, Serum IGFBP-1 levels were in the low normal range and not correlated with any of the other parameters. Treatment with octreotide nasal powder induced in all patients a marked decrease of GH which lowered below 5 C μg/l in 7/8 patients and IGF-1 levels, which fell within the normal range in 1 patient. Serum IGFBP-3 and insulin concentrations decreased by 26% and 71%, respectively, and those of IGFBP-1 underwent an only transient increase in 5/8 patients. Opposite changes of insulin and IGFBP-1 levels, with a decrease of the former followed by an increase of the latter were noted during the 8 hours following an octreotide nasal insufflation. During chronic octreotide treatment, positive correlations were found between GH and IGF-1, GH and IGFBP-3, IGF-1 and IGFBP-3, insulin and IGFBP-3 and insulin and IGF-1. An improvement of the clinical picture was registered in all patients after a few days of octreotide nasal powder administration. Treatment was well tolerated, with only mild side effects and no significant changes in the nasal mucosa, and the patients' compliance was excellent.
| Original language | English |
|---|---|
| Pages (from-to) | 548-555 |
| Number of pages | 8 |
| Journal | Journal of Endocrinological Investigation |
| Volume | 19 |
| Issue number | 8 |
| Publication status | Published - Sep 1996 |
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Keywords
- Acromegaly
- GH
- IGF-1
- IGFBP-1
- IGFBP-3
- Octreotide nasal powder
- Somatostatin
ASJC Scopus subject areas
- Endocrinology
Cite this
Effect of chronic treatment with octreotide nasal powder on serum levels of growth hormone, insulin-like growth factor 1, insulin-like growth factor binding proteins 1 and 3 in acromegalic patients. / Invitti, C.; Fatti, L.; Camboni, M. G.; Porcu, L.; Danesi, L.; Delitala, G.; Cavagnini, F.
In: Journal of Endocrinological Investigation, Vol. 19, No. 8, 09.1996, p. 548-555.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of chronic treatment with octreotide nasal powder on serum levels of growth hormone, insulin-like growth factor 1, insulin-like growth factor binding proteins 1 and 3 in acromegalic patients
AU - Invitti, C.
AU - Fatti, L.
AU - Camboni, M. G.
AU - Porcu, L.
AU - Danesi, L.
AU - Delitala, G.
AU - Cavagnini, F.
PY - 1996/9
Y1 - 1996/9
N2 - Octreotide nasal powder is a delivery system of the somatostatin analogue developed to overcome the inconvenience of repeated subcutaneous administrations. Eight patients with clinically active acromegaly were treated for three months with octreotide nasal powder which was administered at the initial dosage of 0.125 mg tid, doubling the dosage up to 2 mg tid in order to obtain a mean GH value below 5 μg/l during 8 daytime hours. In 4 of these patients, treatment was prolonged till the sixth month. Blood samples were taken on days 15, 29, 43, 55, 90, 120, 150, 180 for GH, IGF-1, IGFBP-3, IGFBP-1 and insulin measurements. Before treatment, mean daytime GH and morning IGF-1 serum levels were both increased but not correlated with each other. Serum IGFBP-3 levels were higher than normal and positively correlated with those of GH, IGF-1 and insulin, Insulin levels were elevated and positively correlated with those of GH but not with those of IGF-1 and IGFBP-1, Serum IGFBP-1 levels were in the low normal range and not correlated with any of the other parameters. Treatment with octreotide nasal powder induced in all patients a marked decrease of GH which lowered below 5 C μg/l in 7/8 patients and IGF-1 levels, which fell within the normal range in 1 patient. Serum IGFBP-3 and insulin concentrations decreased by 26% and 71%, respectively, and those of IGFBP-1 underwent an only transient increase in 5/8 patients. Opposite changes of insulin and IGFBP-1 levels, with a decrease of the former followed by an increase of the latter were noted during the 8 hours following an octreotide nasal insufflation. During chronic octreotide treatment, positive correlations were found between GH and IGF-1, GH and IGFBP-3, IGF-1 and IGFBP-3, insulin and IGFBP-3 and insulin and IGF-1. An improvement of the clinical picture was registered in all patients after a few days of octreotide nasal powder administration. Treatment was well tolerated, with only mild side effects and no significant changes in the nasal mucosa, and the patients' compliance was excellent.
AB - Octreotide nasal powder is a delivery system of the somatostatin analogue developed to overcome the inconvenience of repeated subcutaneous administrations. Eight patients with clinically active acromegaly were treated for three months with octreotide nasal powder which was administered at the initial dosage of 0.125 mg tid, doubling the dosage up to 2 mg tid in order to obtain a mean GH value below 5 μg/l during 8 daytime hours. In 4 of these patients, treatment was prolonged till the sixth month. Blood samples were taken on days 15, 29, 43, 55, 90, 120, 150, 180 for GH, IGF-1, IGFBP-3, IGFBP-1 and insulin measurements. Before treatment, mean daytime GH and morning IGF-1 serum levels were both increased but not correlated with each other. Serum IGFBP-3 levels were higher than normal and positively correlated with those of GH, IGF-1 and insulin, Insulin levels were elevated and positively correlated with those of GH but not with those of IGF-1 and IGFBP-1, Serum IGFBP-1 levels were in the low normal range and not correlated with any of the other parameters. Treatment with octreotide nasal powder induced in all patients a marked decrease of GH which lowered below 5 C μg/l in 7/8 patients and IGF-1 levels, which fell within the normal range in 1 patient. Serum IGFBP-3 and insulin concentrations decreased by 26% and 71%, respectively, and those of IGFBP-1 underwent an only transient increase in 5/8 patients. Opposite changes of insulin and IGFBP-1 levels, with a decrease of the former followed by an increase of the latter were noted during the 8 hours following an octreotide nasal insufflation. During chronic octreotide treatment, positive correlations were found between GH and IGF-1, GH and IGFBP-3, IGF-1 and IGFBP-3, insulin and IGFBP-3 and insulin and IGF-1. An improvement of the clinical picture was registered in all patients after a few days of octreotide nasal powder administration. Treatment was well tolerated, with only mild side effects and no significant changes in the nasal mucosa, and the patients' compliance was excellent.
KW - Acromegaly
KW - GH
KW - IGF-1
KW - IGFBP-1
KW - IGFBP-3
KW - Octreotide nasal powder
KW - Somatostatin
UR - http://www.scopus.com/inward/record.url?scp=0029844165&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029844165&partnerID=8YFLogxK
M3 - Article
C2 - 8905479
AN - SCOPUS:0029844165
VL - 19
SP - 548
EP - 555
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 8
ER -