TY - JOUR
T1 - Effect of cicloxilic acid on bile lipid composition in patients with gallstones
T2 - A multicenter trial
AU - Carulli, Nicola
AU - Ponz de Leon, Maurizio
AU - Podda, Mauro
AU - Di Padova, Carlo
AU - Zuin, Massimo
PY - 1983
Y1 - 1983
N2 - 24 gallstone patients were treated with cicloxilic acid, an agent endowed with choleretic activity, at the dose of 240 mg/day for 1 month. 24 comparable patients on placebo treatment acted as controls. Bile lipid composition was determined and the saturation index calculated before and after treatment, on samples collected by duodenal siphonage after caerulein stimulation, in both groups. In the cicloxilic group there was little or no change in bile salts and phospholipids, whereas biliary cholesterol concentration was significantly reduced (p <0.05) and consequently the lithogenic index lowered (from 1.5 to 1.2, p <0.01). Cicloxilic acid can have a place in gallstone disease therapy in association with the litholytic bile acids or in the prevention of gallstone formation in high-risk populations.
AB - 24 gallstone patients were treated with cicloxilic acid, an agent endowed with choleretic activity, at the dose of 240 mg/day for 1 month. 24 comparable patients on placebo treatment acted as controls. Bile lipid composition was determined and the saturation index calculated before and after treatment, on samples collected by duodenal siphonage after caerulein stimulation, in both groups. In the cicloxilic group there was little or no change in bile salts and phospholipids, whereas biliary cholesterol concentration was significantly reduced (p <0.05) and consequently the lithogenic index lowered (from 1.5 to 1.2, p <0.01). Cicloxilic acid can have a place in gallstone disease therapy in association with the litholytic bile acids or in the prevention of gallstone formation in high-risk populations.
KW - Bile lipid composition
KW - Cholesterol gallstones
KW - Cicloxilic acid
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U2 - 10.1159/000198971
DO - 10.1159/000198971
M3 - Article
C2 - 6360773
AN - SCOPUS:0021029766
VL - 28
SP - 102
EP - 107
JO - Digestion
JF - Digestion
SN - 0012-2823
IS - 2
ER -