Effect of cicloxilic acid on bile lipid composition in patients with gallstones: A multicenter trial

Nicola Carulli, Maurizio Ponz de Leon, Mauro Podda, Carlo Di Padova, Massimo Zuin

Research output: Contribution to journalArticlepeer-review

Abstract

24 gallstone patients were treated with cicloxilic acid, an agent endowed with choleretic activity, at the dose of 240 mg/day for 1 month. 24 comparable patients on placebo treatment acted as controls. Bile lipid composition was determined and the saturation index calculated before and after treatment, on samples collected by duodenal siphonage after caerulein stimulation, in both groups. In the cicloxilic group there was little or no change in bile salts and phospholipids, whereas biliary cholesterol concentration was significantly reduced (p <0.05) and consequently the lithogenic index lowered (from 1.5 to 1.2, p <0.01). Cicloxilic acid can have a place in gallstone disease therapy in association with the litholytic bile acids or in the prevention of gallstone formation in high-risk populations.

Original languageEnglish
Pages (from-to)102-107
Number of pages6
JournalDigestion
Volume28
Issue number2
DOIs
Publication statusPublished - 1983

Keywords

  • Bile lipid composition
  • Cholesterol gallstones
  • Cicloxilic acid

ASJC Scopus subject areas

  • Gastroenterology

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