Effect of cognitive training on the expression of brain-derived neurotrophic factor in lymphocytes of mild cognitive impairment patients

Tiziana Casoli, Cinzia Giuli, Marta Balietti, Belinda Giorgetti, Moreno Solazzi, Patrizia Fattoretti

Research output: Contribution to journalArticlepeer-review

Abstract

To identify biomarkers associated with cognitive stimulation of mild cognitive impairment (MCI) patients, we performed quantitative real-time reverse transcriptase polymerase chain reaction for brain-derived neurotrophic factor (BDNF) mRNA in peripheral lymphocytes of MCI and healthy subjects undergoing a multi-component cognitive training (CT) program. CT determined a significant decrease of BDNF mRNA levels in MCI (fold change=0.31) as compared to healthy subjects (fold change=0.86). It has been reported that in MCI there is an increase of BDNF serum levels, and our findings could indicate a positive effect of CT in restoring pre-disease levels of expression.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalRejuvenation Research
Volume17
Issue number2
DOIs
Publication statusPublished - Apr 1 2014

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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