Effect of colectomy with ileo-anal anastomosis on the biliary lipids

G. Galatola, M. Fracchia, R. P. Jazrawi

Research output: Contribution to journalArticlepeer-review

Abstract

Total colectomy with ileo-anal anastomosis is an effective treatment for ulcerative colitis and familial adenomatous polyposis. The absence of the colon and the coexistence of bile acid malabsorption may increase bile lithogenicity, but data on biliary lipid composition in patients with this operation is lacking. Our aim was to assess bile lithogenicity, bile composition and mass of biliary lipids within the gallbladder. We studied 11 patients with total colectomy and ileo-anal anastomosis and 16 healthy controls. We measured the percentage composition of conjugated bile acids and the masses within the gallbladder of the three main biliary lipids. This method, in contrast with measurement of cholesterol saturation index, can determine the cause of bile lithogenicity in terms of absolute modifications of the biliary lipids. There was no difference in the cholesterol saturation index between patients and controls. Colectomy patients had reduced masses of all three biliary lipids (medians and ranges, mmol): cholesterol 0.11 (0.03-0.24) vs. 0.36 (0.02-0.96), P

Original languageEnglish
Pages (from-to)534-538
Number of pages5
JournalEuropean Journal of Clinical Investigation
Volume25
Issue number7
Publication statusPublished - 1995

Keywords

  • Biliary lipids
  • Cholelithiasis
  • Deoxycholic acid
  • Ileo-anal anastomosis

ASJC Scopus subject areas

  • Medicine(all)

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