TY - JOUR
T1 - Effect of combined treatment with gonadotropin releasing hormone analogue and growth hormone in patients with central precocious puberty who had subnormal growth velocity and impaired height prognosis
AU - Saggese, G.
AU - Pasquino, A. M.
AU - Bertelloni, S.
AU - Baroncelli, G. I.
AU - Battini, R.
AU - Pucarelli, I.
AU - Segni, M.
AU - Franchi, G.
PY - 1995
Y1 - 1995
N2 - Growth hormone-insulin-like growth factor-I status and response to growth hormone therapy (0.6 IU/kg/week sc, six times a week for 12 months) were evaluated in 12 girls (chronological age 9.4 ± 1.6 years) suffering from central precocious puberty with growth velocity less than 4 cm/year and no substantial increase or decrease in predicted adult height during gonadotropin releasing hormone (Gn-RH) analogue treatment (D-Trp6-LH-RH, 60 μg/kg im/28 days). At baseline, large variations were observed in nocturnal growth hormone (GH) means (pathological values (<3.6 μg/l) 33.3%), stimulated levodopa GH peaks (pathological values (
AB - Growth hormone-insulin-like growth factor-I status and response to growth hormone therapy (0.6 IU/kg/week sc, six times a week for 12 months) were evaluated in 12 girls (chronological age 9.4 ± 1.6 years) suffering from central precocious puberty with growth velocity less than 4 cm/year and no substantial increase or decrease in predicted adult height during gonadotropin releasing hormone (Gn-RH) analogue treatment (D-Trp6-LH-RH, 60 μg/kg im/28 days). At baseline, large variations were observed in nocturnal growth hormone (GH) means (pathological values (<3.6 μg/l) 33.3%), stimulated levodopa GH peaks (pathological values (
KW - Central precocious puberty
KW - Gn-RH analogue treatment
KW - Growth hormone
KW - Growth velocity
KW - Predicted adult height
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M3 - Article
C2 - 7780252
AN - SCOPUS:0028954958
VL - 84
SP - 299
EP - 304
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
SN - 0803-5253
IS - 3
ER -