Effect of common carotid occlusion on β-adrenergic receptor function in cerebral microvessels

Maria Sandra Magnoni, Hideyuki Kobayashi, Ludovico Frattola, Pier Franco Spano, Marco Trabucchi

Research output: Contribution to journalArticle

Abstract

β-adrenergic receptors were measured in cerebral microvessels of gerbils and rats after ligature of the right or left common carotid artery. The results indicate a decrease in the number of β-adrenergic receptors in brain microvessels of both ipsilateral and contralateral hemispheres. This event may reflect altered patterns of the neuronal regulation of brain microvasculature and may be related to cerebro vascular alterations which are concomitant with ischemia. Furthermore, the results show that the decrease in β-receptor density is more pronounced in the left hemisphere, independently on the side of carotid occlusion. This finding suggests that micro vessel function in the left side of the brain is more vulnerable to hypoxia effects.

Original languageEnglish
Pages (from-to)505-509
Number of pages5
JournalStroke
Volume16
Issue number3
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Neuroscience(all)

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    Magnoni, M. S., Kobayashi, H., Frattola, L., Spano, P. F., & Trabucchi, M. (1985). Effect of common carotid occlusion on β-adrenergic receptor function in cerebral microvessels. Stroke, 16(3), 505-509.