Effect of computer-aided management on the quality of treatment in anticoagulated patients: A prospective, randomized, multicenter trial of APROAT (Automated Program for Oral Anticoagulant Treatment)

C. Manotti, M. Moia, G. Palareti, V. Pengo, L. Ria, A. G. Dettori

Research output: Contribution to journalArticle

Abstract

Background and Objectives. We carried out a prospective, randomized trial to test whether a computer-based decision support system to initiate and maintain oral anticoagulant (OA) treatment can improve the laboratory quality of therapy. Design and Methods. Two separate sets of patients on oral anticoagulants, in five Italian anticoagulant clinics, were studied: 335 patients in the first three months of treatment (stabilization phase), 916 patients (775 patient-years) beyond the third month of treatment (maintenance phase). Patients were randomized to a computerized system, which included algorithms able to suggest OA dosing and to schedule appointments (computer-aided dosing) or to an arm in which OA were prescribed by the same teams of expert physicians without such algorithms (control group). Primary outcomes were: A) the percentage of patients reaching a stable state of anticoagulation during each of the first three months of treatment; B) the percentage of time individuals spent within the aimed therapeutic range (maintenance phase). Results. Patients in the computer-aided dosing group achieved a stable state significantly faster (p

Original languageEnglish
Pages (from-to)1060-1070
Number of pages11
JournalHaematologica
Volume86
Issue number10
Publication statusPublished - 2001

Keywords

  • Computer-aided management
  • Oral anticoagulant therapy
  • Treatment quality

ASJC Scopus subject areas

  • Hematology

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