Effect of corticoids on neutrophil function

Inhibition of antibody-dependent cell, mediated cytotoxicity (ADCC)

F. Capsoni, P. L. Mroni, M. R. Zocchi, A. M. Plebani, M. Vezio

Research output: Contribution to journalArticle

Abstract

Hydrocortisone sodium succinate (HC) inhibited "in vitro" neutrophil-mediated abtibody-depndent cellular cytotoxicity (ADCC). The drug effect was dose-depedent and completely reversible. The killing defect was partially overcome by increasing the density of the antibody on the target cells. However, HC added after the binding between effector and target cells was still able to inhibit in a similar dos-dependent way the cytotoxic activity. Gur results suggest that HC interferes in a later step, after the effector/target interaction. Methyl-prednisolone and dexamethasone as well as HC were found to inhibit in a dose-dependent manner the neutrophil-mediated ADCC, whereas testosterone did not have any effect.

Original languageEnglish
Pages (from-to)217-230
Number of pages14
JournalImmunopharmacology and Immunotoxicology
Volume5
Issue number3
DOIs
Publication statusPublished - 1983

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Antibody-Dependent Cell Cytotoxicity
Cytotoxicity
Adrenal Cortex Hormones
Neutrophils
Cells
Antibodies
Succinic Acid
Prednisolone
Dexamethasone
Hydrocortisone
Testosterone
Sodium
Defects
Pharmaceutical Preparations
Gur
cortisol succinate
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology

Cite this

Effect of corticoids on neutrophil function : Inhibition of antibody-dependent cell, mediated cytotoxicity (ADCC). / Capsoni, F.; Mroni, P. L.; Zocchi, M. R.; Plebani, A. M.; Vezio, M.

In: Immunopharmacology and Immunotoxicology, Vol. 5, No. 3, 1983, p. 217-230.

Research output: Contribution to journalArticle

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