Effect of corticotrophin-releasing hormone on arginine vasopressin and atrial natriuretic factor in patients with Cushing's disease

Annamaria Colao, Rosario Pivonello, Diego Ferone, Antongiulio Faggiano, Giuseppina Facciolli, Carolina Di Somma, Françoise Boudouresque, Charles Oliver, Gaetano Lombardi

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To evaluate the effect of CRH administration on plasma AVP and ANF concentration in patients with Cushing's disease and healthy subjects. SUBJECTS: Fifteen patients with Cushing's disease and 15 sex- and age-matched healthy subjects entered the study. STUDY DESIGN: All subjects were randomly given i.v. 100 μg hCRH and placebo (NaCl 0.9%) on two non consecutive days. Blood samples for plasma AVP and ANF assay were taken before and every 15 min for 2 hr after CRH or placebo. Five out of the 15 patients with Cushing's disease underwent a repeat CRH test after surgical cure of the disease. RESULTS: At baseline evaluation, plasma ANF concentrations were significantly higher in patients with Cushing's disease compared to healthy subjects (15.0 ± 0.8 vs 10.8 ± 0.6 pmol/l, P

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalClinical Endocrinology
Volume49
Issue number1
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Endocrinology

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