Effect of crosslinking agent to design nanostructured hyaluronic acid-based hydrogels with improved relaxometric properties

Franca De Sarno, Alfonso Maria Ponsiglione, Anna Maria Grimaldi, Paolo Antonio Netti, Enza Torino

Research output: Contribution to journalArticle

Abstract

Nowadays, natural polysaccharides have given promising results as drug carriers. Among them, the hydrogels, thanks to their versatile properties, have been produced and engineered at the nano-scale in order to develop nanovectors for diagnostic and therapeutic purposes. Here, we investigate the contribution that a natural biopolymer, hyaluronic acid (HA), can give to the field of Magnetic Resonance Imaging (MRI). In addition, we study the relaxometric properties of crosslinked and non-crosslinked hydrogel networks and outline the impact of both HA concentration and crosslinker, Divinyl Sulfone (DVS), on the relaxivity of aqueous polymer solutions, even in the absence of Contrast Agents (CAs). Results show that proper HA concentration and the presence of the crosslinking agent can enhance the longitudinal relaxation time of the surrounding water, even in the absence of CAs. These findings could inspire the design of novel nanostructured hydrogels with enhanced relaxometric properties for MRI applications and not only.

Original languageEnglish
Article number114991
JournalCarbohydrate Polymers
Volume222
DOIs
Publication statusPublished - Oct 15 2019

Keywords

  • Biopolymer
  • Hyaluronic acid
  • Hydrogel
  • MRI
  • Relaxivity

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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