Abstract
Cyclophosphamide (CP) injected at different treatment schedules into CD male rats, prolongs narcosis after either parenteral or oral administration of pentobarbital. However, it takes 7 days before any change appears after CP pretreatment. The level of pentobarbital in blood and brain at different times after injection was higher in CP pretreated than in untreated animals. Since previous studies reported a decreased rate of inactivation of drugs after treatment with cytotoxic agents, experiments were performed to ascertain whether, beside the impairment of the metabolism, the animals respond differently to the same brain concentration of pentobarbital.
| Original language | English |
|---|---|
| Pages (from-to) | 2609-2614 |
| Number of pages | 6 |
| Journal | Biochemical Pharmacology |
| Volume | 22 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - Oct 15 1973 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Effect of cyclophosphamide on the activity and distribution of pentobarbital in rats. / Donelli, Maria Grazia; Colombo, Tina; Garattini, Silvio.
In: Biochemical Pharmacology, Vol. 22, No. 20, 15.10.1973, p. 2609-2614.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of cyclophosphamide on the activity and distribution of pentobarbital in rats
AU - Donelli, Maria Grazia
AU - Colombo, Tina
AU - Garattini, Silvio
PY - 1973/10/15
Y1 - 1973/10/15
N2 - Cyclophosphamide (CP) injected at different treatment schedules into CD male rats, prolongs narcosis after either parenteral or oral administration of pentobarbital. However, it takes 7 days before any change appears after CP pretreatment. The level of pentobarbital in blood and brain at different times after injection was higher in CP pretreated than in untreated animals. Since previous studies reported a decreased rate of inactivation of drugs after treatment with cytotoxic agents, experiments were performed to ascertain whether, beside the impairment of the metabolism, the animals respond differently to the same brain concentration of pentobarbital.
AB - Cyclophosphamide (CP) injected at different treatment schedules into CD male rats, prolongs narcosis after either parenteral or oral administration of pentobarbital. However, it takes 7 days before any change appears after CP pretreatment. The level of pentobarbital in blood and brain at different times after injection was higher in CP pretreated than in untreated animals. Since previous studies reported a decreased rate of inactivation of drugs after treatment with cytotoxic agents, experiments were performed to ascertain whether, beside the impairment of the metabolism, the animals respond differently to the same brain concentration of pentobarbital.
UR - http://www.scopus.com/inward/record.url?scp=0015840692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015840692&partnerID=8YFLogxK
U2 - 10.1016/0006-2952(73)90069-5
DO - 10.1016/0006-2952(73)90069-5
M3 - Article
C2 - 4749717
AN - SCOPUS:0015840692
VL - 22
SP - 2609
EP - 2614
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
IS - 20
ER -