Effect of cyclosporine and aminophylline on streptozotocin-induced diabetes in rats

Elisabetta Ferrero, Antonio Marni, Maria Elena Ferrero, Gianfranco Gaja, Claudio Rugarli

Research output: Contribution to journalArticle

Abstract

Diabetes induced in rats by multiple low doses of streptozotocin is thought to mimic type 1 disease in man. We tested the effect of concomitant treatment with immunomodulator drugs in this diabetic experimental model. Administration of cyclosporine resulted in a rapid appearance of hyperglycemia, perhaps by a potentiation of the direct cytotoxic action of streptozotocin on beta cells. By contrast, aminophylline administration protected the animals from the diabetogenic action of streptozotocin. Concomitant treatment with aminophylline and cyclosporine failed to protect the rats from the hyperglycemia induced by streptozotocin.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalImmunology Letters
Volume10
Issue number3-4
DOIs
Publication statusPublished - 1985

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Aminophylline
Experimental Diabetes Mellitus
Streptozocin
Cyclosporine
Hyperglycemia
Immunologic Factors
Theoretical Models
Therapeutics
Pharmaceutical Preparations

Keywords

  • aminophylline
  • cyclosporine
  • diabetes
  • immunosuppression

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Effect of cyclosporine and aminophylline on streptozotocin-induced diabetes in rats. / Ferrero, Elisabetta; Marni, Antonio; Ferrero, Maria Elena; Gaja, Gianfranco; Rugarli, Claudio.

In: Immunology Letters, Vol. 10, No. 3-4, 1985, p. 183-187.

Research output: Contribution to journalArticle

Ferrero, Elisabetta ; Marni, Antonio ; Ferrero, Maria Elena ; Gaja, Gianfranco ; Rugarli, Claudio. / Effect of cyclosporine and aminophylline on streptozotocin-induced diabetes in rats. In: Immunology Letters. 1985 ; Vol. 10, No. 3-4. pp. 183-187.
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