Effect of cyclosporine on hepatic cytosolic estrogen and androgen receptor levels before and after partial hepatectomy

D. Kahn, J. S. Gavaler, H. Lai, L. Makowka, P. K. Eagon, A. Francavilla, T. E. Starzl, D. H. Van Thiel

Research output: Contribution to journalArticlepeer-review

Abstract

Estrogen and androgen receptors within the liver have been reported to modulate the hepatic regenerative response to partial hepatectomy. Moreover, cyclosporine has several untoward effects that might occur as a consequence of alterations in sex hormone activity. To evaluate these questions the following experiments were performed. Estrogen and androgen receptors in cytosol were quantitated in livers of rats treated with cyclosporine or olive oil vehicle before and after partial hepatectomy or a sham operation. Ornithine decarboxylase activity and thymidine kinase activity were assessed as indices of hepatic regeneration. Preoperative levels of estrogen receptor activity in the hepatic cytosol were significantly greater in rats treated with cyclosporine as compared to vehicle treated controls (P

Original languageEnglish
Pages (from-to)6-11
Number of pages6
JournalDigestive Diseases and Sciences
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 1990

Keywords

  • androgen
  • cyclosporine
  • cytosol
  • estrogen
  • hepatectomy

ASJC Scopus subject areas

  • Gastroenterology

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