Abstract
Five patients with metastatic renal cell cancer (RCC) entered this study. The patients received two courses of teniposide (VM26) (200 mg/m2/24 h i.v.) after which no objective response was observed: three patients had stable disease (SD) and two had progressive disease. Cyclosporine (CsA) (5 mg/kg/2 h followed by 30 mg/kg/48 h i.v.) was then added (VM26/Csa) and at least another two courses were administered. Pharmacokinetic and pharmacodynamic parameters were analyzed. CsA increased the area under curve (AUC) of VM26 in four out of five patients; on average, the variation in the paired AUC of VM26 was 41%. Nadir granulocyte count was lower (average 650/mm3, ranging from <100 to 1800/mm3) after VM26/CsA than after VM26 (average 1260/mm3, ranging from 200 to 2100/mm3) (p <0.01). Bilirubin concentration in the serum was increased after VM26/CsA compared with VM26 (p <0.05). Finally, after two courses of VM26/CsA, four patients had stable disease and one patient had a minor response. In conclusion, the ongoing pilot study indicates that CsA affects both the pharmacokinetics and the pharmacodynamics of VM26.
Original language | English |
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Pages (from-to) | 479-482 |
Number of pages | 4 |
Journal | Anti-Cancer Drugs |
Volume | 6 |
Issue number | 3 |
Publication status | Published - 1995 |
Keywords
- cyclosporine
- MDR
- renal cell cancer
- teniposide
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Pharmacology