Effect of cyclosporine on the antigen-presenting function of human and murine accessory cells

Fabrizio Manca, Daniela Fenoglio, Annalisa Kunkl, Marta Caltabellotta, Franco Celada

Research output: Contribution to journalArticle

Abstract

Recent reports have challenged the belief that accessory cells are resistant to cyclosporine. Such a tenet was based on the observation that several functions of accessory cells, such as IL-1 production and phagocytosis, are resistant to the drug. On the other hand, when a less primitive, more refined function of accessory cells was examined— i.e., the capacity to take up, process, and present antigen in an MHC-restricted fashion to antigen- specific T lymphocytes, CsA proved to be an effective inhibitor. In contrast to this finding, when antigen was provided in the form of an immune complex prepared with a monoclonal antibody, uptake of antigen— lilkely mediated by the Fc receptors— and subsequent processing and presentation were not affected by CsA.

Original languageEnglish
Pages (from-to)40S-43S
JournalTransplantation
Volume46
Issue number2
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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    Manca, F., Fenoglio, D., Kunkl, A., Caltabellotta, M., & Celada, F. (1988). Effect of cyclosporine on the antigen-presenting function of human and murine accessory cells. Transplantation, 46(2), 40S-43S.