Recent reports have challenged the belief that accessory cells are resistant to cyclosporine. Such a tenet was based on the observation that several functions of accessory cells, such as IL-1 production and phagocytosis, are resistant to the drug. On the other hand, when a less primitive, more refined function of accessory cells was examined— i.e., the capacity to take up, process, and present antigen in an MHC-restricted fashion to antigen- specific T lymphocytes, CsA proved to be an effective inhibitor. In contrast to this finding, when antigen was provided in the form of an immune complex prepared with a monoclonal antibody, uptake of antigen— lilkely mediated by the Fc receptors— and subsequent processing and presentation were not affected by CsA.
|Publication status||Published - 1988|
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