Effect of cyclosporine on the antigen-presenting function of human and murine accessory cells

Fabrizio Manca, Daniela Fenoglio, Annalisa Kunkl, Marta Caltabellotta, Franco Celada

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Recent reports have challenged the belief that accessory cells are resistant to cyclosporine. Such a tenet was based on the observation that several functions of accessory cells, such as IL-1 production and phagocytosis, are resistant to the drug. On the other hand, when a less primitive, more refined function of accessory cells was examined— i.e., the capacity to take up, process, and present antigen in an MHC-restricted fashion to antigen- specific T lymphocytes, CsA proved to be an effective inhibitor. In contrast to this finding, when antigen was provided in the form of an immune complex prepared with a monoclonal antibody, uptake of antigen— lilkely mediated by the Fc receptors— and subsequent processing and presentation were not affected by CsA.

Original languageEnglish
Pages (from-to)40S-43S
JournalTransplantation
Volume46
Issue number2
Publication statusPublished - 1988

Fingerprint

Cyclosporine
Antigens
Fc Receptors
Antigen-Antibody Complex
Interleukin-1
Phagocytosis
Monoclonal Antibodies
T-Lymphocytes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Manca, F., Fenoglio, D., Kunkl, A., Caltabellotta, M., & Celada, F. (1988). Effect of cyclosporine on the antigen-presenting function of human and murine accessory cells. Transplantation, 46(2), 40S-43S.

Effect of cyclosporine on the antigen-presenting function of human and murine accessory cells. / Manca, Fabrizio; Fenoglio, Daniela; Kunkl, Annalisa; Caltabellotta, Marta; Celada, Franco.

In: Transplantation, Vol. 46, No. 2, 1988, p. 40S-43S.

Research output: Contribution to journalArticle

Manca, F, Fenoglio, D, Kunkl, A, Caltabellotta, M & Celada, F 1988, 'Effect of cyclosporine on the antigen-presenting function of human and murine accessory cells', Transplantation, vol. 46, no. 2, pp. 40S-43S.
Manca, Fabrizio ; Fenoglio, Daniela ; Kunkl, Annalisa ; Caltabellotta, Marta ; Celada, Franco. / Effect of cyclosporine on the antigen-presenting function of human and murine accessory cells. In: Transplantation. 1988 ; Vol. 46, No. 2. pp. 40S-43S.
@article{1b60afcbbd5d4b1eb2ea6da8b25f555e,
title = "Effect of cyclosporine on the antigen-presenting function of human and murine accessory cells",
abstract = "Recent reports have challenged the belief that accessory cells are resistant to cyclosporine. Such a tenet was based on the observation that several functions of accessory cells, such as IL-1 production and phagocytosis, are resistant to the drug. On the other hand, when a less primitive, more refined function of accessory cells was examined— i.e., the capacity to take up, process, and present antigen in an MHC-restricted fashion to antigen- specific T lymphocytes, CsA proved to be an effective inhibitor. In contrast to this finding, when antigen was provided in the form of an immune complex prepared with a monoclonal antibody, uptake of antigen— lilkely mediated by the Fc receptors— and subsequent processing and presentation were not affected by CsA.",
author = "Fabrizio Manca and Daniela Fenoglio and Annalisa Kunkl and Marta Caltabellotta and Franco Celada",
year = "1988",
language = "English",
volume = "46",
pages = "40S--43S",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Effect of cyclosporine on the antigen-presenting function of human and murine accessory cells

AU - Manca, Fabrizio

AU - Fenoglio, Daniela

AU - Kunkl, Annalisa

AU - Caltabellotta, Marta

AU - Celada, Franco

PY - 1988

Y1 - 1988

N2 - Recent reports have challenged the belief that accessory cells are resistant to cyclosporine. Such a tenet was based on the observation that several functions of accessory cells, such as IL-1 production and phagocytosis, are resistant to the drug. On the other hand, when a less primitive, more refined function of accessory cells was examined— i.e., the capacity to take up, process, and present antigen in an MHC-restricted fashion to antigen- specific T lymphocytes, CsA proved to be an effective inhibitor. In contrast to this finding, when antigen was provided in the form of an immune complex prepared with a monoclonal antibody, uptake of antigen— lilkely mediated by the Fc receptors— and subsequent processing and presentation were not affected by CsA.

AB - Recent reports have challenged the belief that accessory cells are resistant to cyclosporine. Such a tenet was based on the observation that several functions of accessory cells, such as IL-1 production and phagocytosis, are resistant to the drug. On the other hand, when a less primitive, more refined function of accessory cells was examined— i.e., the capacity to take up, process, and present antigen in an MHC-restricted fashion to antigen- specific T lymphocytes, CsA proved to be an effective inhibitor. In contrast to this finding, when antigen was provided in the form of an immune complex prepared with a monoclonal antibody, uptake of antigen— lilkely mediated by the Fc receptors— and subsequent processing and presentation were not affected by CsA.

UR - http://www.scopus.com/inward/record.url?scp=0023787005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023787005&partnerID=8YFLogxK

M3 - Article

C2 - 3261466

AN - SCOPUS:0023787005

VL - 46

SP - 40S-43S

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 2

ER -