Effect of [D-Ala2,MePhe4,Gly-ol5]enkephalin and [D-Ala2,D-Leu5]enkephalin on ion and amino acid transport in rabbit ileum.

G. Meyer, G. Botta, A. Tavani, S. Algeri, D. Cremaschi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The selective mu-opioid agonist [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAGO) (10 microM) reduced the short circuit (Isc) and the L-valine induced increase of the transepithelial potential difference and Isc(delta Vms and delta Isc) measured in-vitro in rabbit ileum, with a mechanism antagonized by naloxone (1 microM). [D-Ala2,D-Leu5]enkephalin (DADLE) (10 microM) had no significant effect on the transepithelial potential difference (Vms), Isc, delta Vms and delta Isc. In the ileum deprived of the serosa and muscolaris, DAGO reduced the delta Vms and delta Isc, but not the Vms and Isc, suggesting localization of the receptors responsible for this latter effect in the myenteric plexus and/or the muscularis mucosae. These preliminary results suggest that in the rabbit ileum opioids influence electrolyte and amino acid transport and these effects may be at least partly mediated by mu-receptors.

Original languageEnglish
Pages (from-to)494-495
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume41
Issue number7
Publication statusPublished - Jul 1989

Fingerprint

Ileum
Enkephalins
Ions
Rabbits
Amino Acids
Opioid Analgesics
Serous Membrane
Myenteric Plexus
mu Opioid Receptor
Valine
Naloxone
Electrolytes
Mucous Membrane
Ala(2)-enkephalinamide-met

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Effect of [D-Ala2,MePhe4,Gly-ol5]enkephalin and [D-Ala2,D-Leu5]enkephalin on ion and amino acid transport in rabbit ileum. / Meyer, G.; Botta, G.; Tavani, A.; Algeri, S.; Cremaschi, D.

In: Journal of Pharmacy and Pharmacology, Vol. 41, No. 7, 07.1989, p. 494-495.

Research output: Contribution to journalArticle

Meyer, G. ; Botta, G. ; Tavani, A. ; Algeri, S. ; Cremaschi, D. / Effect of [D-Ala2,MePhe4,Gly-ol5]enkephalin and [D-Ala2,D-Leu5]enkephalin on ion and amino acid transport in rabbit ileum. In: Journal of Pharmacy and Pharmacology. 1989 ; Vol. 41, No. 7. pp. 494-495.
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