Effect of diazepam on 24-hour blood pressure and heart rate in healthy young volunteers

Alfredo Costa, Daniele Bosone, Annalisa Zoppi, Angela D'Aposangelo, Natascia Ghiotto, Elena Guaschino, Matteo Cotta Ramusino, Roberto Fogari

Research output: Contribution to journalArticle

Abstract

Aim: To assess the effects of evening chronic administration of diazepam on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. Methods: This randomized double blind, cross-over study evaluated the effects of diazepam 5 mg or placebo, both ingested in the evening, on 24-h ambulatory BP and HR in healthy subjects aged 21-30. Results: A total of 30 subjects were included in the analysis. At the end of 4-week diazepam intake, an increase in 24-h HR mean values was found (+5.2 beats/min, p < 0.05). Analysis of subperiods showed that diazepam produced a 10.1% increase in night-time HR (+6.1 beats/min, p < 0.01) without affecting BP. A significant HR rise (+4.9 beats/min, p < 0.05) and SBP reduction (-3.8 mm Hg, p < 0.05) were observed in the morning hours. The HR increase persisted in day-time hours (+4.6 beats/min, p < 0.05), while BP values resulted unaffected. Conclusions: In healthy subjects, diazepam taken as a hypnotic agent induces a significant HR increase, possibly mediated by a decrease in vagal tone. This effect might be of clinical relevance due to the role that HR plays as an independent cardiovascular risk factor.

Original languageEnglish
Pages (from-to)86-91
Number of pages6
JournalPharmacology
Volume101
Issue number1-2
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Diazepam
Healthy Volunteers
Heart Rate
Blood Pressure
Hypnotics and Sedatives
Cross-Over Studies
Young Adult
Placebos

Keywords

  • Diazepam
  • Healthy volunteers
  • Heart rate
  • Twenty-four hour blood pressure

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of diazepam on 24-hour blood pressure and heart rate in healthy young volunteers. / Costa, Alfredo; Bosone, Daniele; Zoppi, Annalisa; D'Aposangelo, Angela; Ghiotto, Natascia; Guaschino, Elena; Cotta Ramusino, Matteo; Fogari, Roberto.

In: Pharmacology, Vol. 101, No. 1-2, 01.12.2017, p. 86-91.

Research output: Contribution to journalArticle

Costa, Alfredo ; Bosone, Daniele ; Zoppi, Annalisa ; D'Aposangelo, Angela ; Ghiotto, Natascia ; Guaschino, Elena ; Cotta Ramusino, Matteo ; Fogari, Roberto. / Effect of diazepam on 24-hour blood pressure and heart rate in healthy young volunteers. In: Pharmacology. 2017 ; Vol. 101, No. 1-2. pp. 86-91.
@article{faf0a5f221dc44c499e3dafd13bc4c84,
title = "Effect of diazepam on 24-hour blood pressure and heart rate in healthy young volunteers",
abstract = "Aim: To assess the effects of evening chronic administration of diazepam on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. Methods: This randomized double blind, cross-over study evaluated the effects of diazepam 5 mg or placebo, both ingested in the evening, on 24-h ambulatory BP and HR in healthy subjects aged 21-30. Results: A total of 30 subjects were included in the analysis. At the end of 4-week diazepam intake, an increase in 24-h HR mean values was found (+5.2 beats/min, p < 0.05). Analysis of subperiods showed that diazepam produced a 10.1{\%} increase in night-time HR (+6.1 beats/min, p < 0.01) without affecting BP. A significant HR rise (+4.9 beats/min, p < 0.05) and SBP reduction (-3.8 mm Hg, p < 0.05) were observed in the morning hours. The HR increase persisted in day-time hours (+4.6 beats/min, p < 0.05), while BP values resulted unaffected. Conclusions: In healthy subjects, diazepam taken as a hypnotic agent induces a significant HR increase, possibly mediated by a decrease in vagal tone. This effect might be of clinical relevance due to the role that HR plays as an independent cardiovascular risk factor.",
keywords = "Diazepam, Healthy volunteers, Heart rate, Twenty-four hour blood pressure",
author = "Alfredo Costa and Daniele Bosone and Annalisa Zoppi and Angela D'Aposangelo and Natascia Ghiotto and Elena Guaschino and {Cotta Ramusino}, Matteo and Roberto Fogari",
year = "2017",
month = "12",
day = "1",
doi = "10.1159/000481665",
language = "English",
volume = "101",
pages = "86--91",
journal = "Pharmacology",
issn = "0031-7012",
publisher = "S. Karger AG",
number = "1-2",

}

TY - JOUR

T1 - Effect of diazepam on 24-hour blood pressure and heart rate in healthy young volunteers

AU - Costa, Alfredo

AU - Bosone, Daniele

AU - Zoppi, Annalisa

AU - D'Aposangelo, Angela

AU - Ghiotto, Natascia

AU - Guaschino, Elena

AU - Cotta Ramusino, Matteo

AU - Fogari, Roberto

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Aim: To assess the effects of evening chronic administration of diazepam on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. Methods: This randomized double blind, cross-over study evaluated the effects of diazepam 5 mg or placebo, both ingested in the evening, on 24-h ambulatory BP and HR in healthy subjects aged 21-30. Results: A total of 30 subjects were included in the analysis. At the end of 4-week diazepam intake, an increase in 24-h HR mean values was found (+5.2 beats/min, p < 0.05). Analysis of subperiods showed that diazepam produced a 10.1% increase in night-time HR (+6.1 beats/min, p < 0.01) without affecting BP. A significant HR rise (+4.9 beats/min, p < 0.05) and SBP reduction (-3.8 mm Hg, p < 0.05) were observed in the morning hours. The HR increase persisted in day-time hours (+4.6 beats/min, p < 0.05), while BP values resulted unaffected. Conclusions: In healthy subjects, diazepam taken as a hypnotic agent induces a significant HR increase, possibly mediated by a decrease in vagal tone. This effect might be of clinical relevance due to the role that HR plays as an independent cardiovascular risk factor.

AB - Aim: To assess the effects of evening chronic administration of diazepam on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. Methods: This randomized double blind, cross-over study evaluated the effects of diazepam 5 mg or placebo, both ingested in the evening, on 24-h ambulatory BP and HR in healthy subjects aged 21-30. Results: A total of 30 subjects were included in the analysis. At the end of 4-week diazepam intake, an increase in 24-h HR mean values was found (+5.2 beats/min, p < 0.05). Analysis of subperiods showed that diazepam produced a 10.1% increase in night-time HR (+6.1 beats/min, p < 0.01) without affecting BP. A significant HR rise (+4.9 beats/min, p < 0.05) and SBP reduction (-3.8 mm Hg, p < 0.05) were observed in the morning hours. The HR increase persisted in day-time hours (+4.6 beats/min, p < 0.05), while BP values resulted unaffected. Conclusions: In healthy subjects, diazepam taken as a hypnotic agent induces a significant HR increase, possibly mediated by a decrease in vagal tone. This effect might be of clinical relevance due to the role that HR plays as an independent cardiovascular risk factor.

KW - Diazepam

KW - Healthy volunteers

KW - Heart rate

KW - Twenty-four hour blood pressure

UR - http://www.scopus.com/inward/record.url?scp=85033367373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033367373&partnerID=8YFLogxK

U2 - 10.1159/000481665

DO - 10.1159/000481665

M3 - Article

AN - SCOPUS:85033367373

VL - 101

SP - 86

EP - 91

JO - Pharmacology

JF - Pharmacology

SN - 0031-7012

IS - 1-2

ER -