Effect of Diazepam on 24-Hour Blood Pressure and Heart Rate in Healthy Young Volunteers

Alfredo Costa, Daniele Bosone, Annalisa Zoppi, Angela D Apos Angelo, Natascia Ghiotto, Elena Guaschino, Matteo Cotta Ramusino, Roberto Fogari

Research output: Contribution to journalArticle

Abstract

AIM: To assess the effects of evening chronic administration of diazepam on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults.

METHODS: This randomized double blind, cross-over study evaluated the effects of diazepam 5 mg or placebo, both ingested in the evening, on 24-h ambulatory BP and HR in healthy subjects aged 21-30.

RESULTS: A total of 30 subjects were included in the analysis. At the end of 4-week diazepam intake, an increase in 24-h HR mean values was found (+5.2 beats/min, p < 0.05). Analysis of subperiods showed that diazepam produced a 10.1% increase in night-time HR (+6.1 beats/min, p < 0.01) without affecting BP. A significant HR rise (+4.9 beats/min, p < 0.05) and SBP reduction (-3.8 mm Hg, p < 0.05) were observed in the morning hours. The HR increase persisted in day-time hours (+4.6 beats/min, p < 0.05), while BP values resulted unaffected.

CONCLUSIONS: In healthy subjects, diazepam taken as a hypnotic agent induces a significant HR increase, possibly mediated by a decrease in vagal tone. This effect might be of clinical relevance due to the role that HR plays as an independent cardiovascular risk factor.

Original languageEnglish
Pages (from-to)86-91
Number of pages6
JournalPharmacology
Volume101
Issue number1-2
DOIs
Publication statusPublished - 2018

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Diazepam
Healthy Volunteers
Heart Rate
Blood Pressure
Hypnotics and Sedatives
Cross-Over Studies
Young Adult
Placebos

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Effect of Diazepam on 24-Hour Blood Pressure and Heart Rate in Healthy Young Volunteers. / Costa, Alfredo; Bosone, Daniele; Zoppi, Annalisa; D Apos Angelo, Angela; Ghiotto, Natascia; Guaschino, Elena; Cotta Ramusino, Matteo; Fogari, Roberto.

In: Pharmacology, Vol. 101, No. 1-2, 2018, p. 86-91.

Research output: Contribution to journalArticle

Costa, Alfredo ; Bosone, Daniele ; Zoppi, Annalisa ; D Apos Angelo, Angela ; Ghiotto, Natascia ; Guaschino, Elena ; Cotta Ramusino, Matteo ; Fogari, Roberto. / Effect of Diazepam on 24-Hour Blood Pressure and Heart Rate in Healthy Young Volunteers. In: Pharmacology. 2018 ; Vol. 101, No. 1-2. pp. 86-91.
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abstract = "AIM: To assess the effects of evening chronic administration of diazepam on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults.METHODS: This randomized double blind, cross-over study evaluated the effects of diazepam 5 mg or placebo, both ingested in the evening, on 24-h ambulatory BP and HR in healthy subjects aged 21-30.RESULTS: A total of 30 subjects were included in the analysis. At the end of 4-week diazepam intake, an increase in 24-h HR mean values was found (+5.2 beats/min, p < 0.05). Analysis of subperiods showed that diazepam produced a 10.1{\%} increase in night-time HR (+6.1 beats/min, p < 0.01) without affecting BP. A significant HR rise (+4.9 beats/min, p < 0.05) and SBP reduction (-3.8 mm Hg, p < 0.05) were observed in the morning hours. The HR increase persisted in day-time hours (+4.6 beats/min, p < 0.05), while BP values resulted unaffected.CONCLUSIONS: In healthy subjects, diazepam taken as a hypnotic agent induces a significant HR increase, possibly mediated by a decrease in vagal tone. This effect might be of clinical relevance due to the role that HR plays as an independent cardiovascular risk factor.",
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T1 - Effect of Diazepam on 24-Hour Blood Pressure and Heart Rate in Healthy Young Volunteers

AU - Costa, Alfredo

AU - Bosone, Daniele

AU - Zoppi, Annalisa

AU - D Apos Angelo, Angela

AU - Ghiotto, Natascia

AU - Guaschino, Elena

AU - Cotta Ramusino, Matteo

AU - Fogari, Roberto

N1 - © 2017 S. Karger AG, Basel.

PY - 2018

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N2 - AIM: To assess the effects of evening chronic administration of diazepam on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults.METHODS: This randomized double blind, cross-over study evaluated the effects of diazepam 5 mg or placebo, both ingested in the evening, on 24-h ambulatory BP and HR in healthy subjects aged 21-30.RESULTS: A total of 30 subjects were included in the analysis. At the end of 4-week diazepam intake, an increase in 24-h HR mean values was found (+5.2 beats/min, p < 0.05). Analysis of subperiods showed that diazepam produced a 10.1% increase in night-time HR (+6.1 beats/min, p < 0.01) without affecting BP. A significant HR rise (+4.9 beats/min, p < 0.05) and SBP reduction (-3.8 mm Hg, p < 0.05) were observed in the morning hours. The HR increase persisted in day-time hours (+4.6 beats/min, p < 0.05), while BP values resulted unaffected.CONCLUSIONS: In healthy subjects, diazepam taken as a hypnotic agent induces a significant HR increase, possibly mediated by a decrease in vagal tone. This effect might be of clinical relevance due to the role that HR plays as an independent cardiovascular risk factor.

AB - AIM: To assess the effects of evening chronic administration of diazepam on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults.METHODS: This randomized double blind, cross-over study evaluated the effects of diazepam 5 mg or placebo, both ingested in the evening, on 24-h ambulatory BP and HR in healthy subjects aged 21-30.RESULTS: A total of 30 subjects were included in the analysis. At the end of 4-week diazepam intake, an increase in 24-h HR mean values was found (+5.2 beats/min, p < 0.05). Analysis of subperiods showed that diazepam produced a 10.1% increase in night-time HR (+6.1 beats/min, p < 0.01) without affecting BP. A significant HR rise (+4.9 beats/min, p < 0.05) and SBP reduction (-3.8 mm Hg, p < 0.05) were observed in the morning hours. The HR increase persisted in day-time hours (+4.6 beats/min, p < 0.05), while BP values resulted unaffected.CONCLUSIONS: In healthy subjects, diazepam taken as a hypnotic agent induces a significant HR increase, possibly mediated by a decrease in vagal tone. This effect might be of clinical relevance due to the role that HR plays as an independent cardiovascular risk factor.

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