Effect of dicarboxylic (C6 and C9) acids on a human squamous carcinoma cell line in cultures

H. C. Patzold, A. S. Breathnach, E. J. Robins, M. E. Daridan, Y. P. Bhasin, L. B. Ethridge, M. Nazzaro-Porro, S. Passi, M. Picardo

Research output: Contribution to journalArticlepeer-review

Abstract

In tissue culture, azelaic acid (C9) has been shown to have an anti-proliferative and cytotoxic effect on human and murine malignant melanocytes, with inhibition of mitochondrial oxido-reductase enzymes and DNA synthesis, and damage to mitochondria. Recent reports of effects on differentiation of normal keratocytes have led to the present study of its effects on a squamous carcinoma cell line. Cells were exposed to single doses of disodium salts of azelaic (C92Na) and adipic (C62Na) acids at concentrations of 10-2 M and 5 x 10-2 M for 48 hrs. Only C92Na at 5 x 10-2 M for 4 hrs., and longer, significantly affected proliferation, and the cells exhibited massive swelling of mitochondria with loss of cristae. The results further confirm the probable value of azelaic acid as a general anti-tumoral agent rather than a specifically melanocytotoxic one. They could justify clinical studies on the effect of topical azelaic acid therapy on squamous cell carcinoma in vivo.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalHistology and Histopathology
Volume4
Issue number2
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Histology
  • Pathology and Forensic Medicine

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