Effect of different fractions of alkaline reflux on the gastric stump and the esophagus: An experimental research on pigs

Gennaro Clemente, Raffaele Manni, Fabio M. Vecchio, Salvatore Rizzo, Sergio Furgiuele, Pasquale Perrotti, Francesco Crucitti

Research output: Contribution to journalArticlepeer-review

Abstract

An experimental study was conducted to evaluate the effect of different fractions (bile and pancreaticoduodenal secretions) on the gastric stump and esophageal mucosa. Twenty pigs underwent partial gastrectomy (two-third distal) and cardiomyotomy in order to induce free gastroesophageal reflux. Then, reconstruction of the alimentary tract was performed to assess the effects of different types of alkaline reflux. A combined (biliary and pancreaticoduodenal) reflux, an isolated biliary reflux, and an isolated pancreaticoduodenal reflux were induced, respectively, in three different groups of five pigs each. In a control group a Roux-en-Y gastrojejunostomy was performed. Nine months later, the animals were sacrificed; the esophagus and the gastric stump were removed for histologic examination. The results show that the most severe histopathological lesions are determined by combined alkaline reflux; on the other hand, separated fractions can induce only mild changes on the gastric stump and esophageal mucosa.

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalJournal of Surgical Research
Volume48
Issue number2
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Surgery

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