Abstract
The binding to human serum albunin of two anti-inflammatory drugs, indomethacin and indoprofen, has been studied by chromatographic and spectroscopic techniques. The results shown indicate that the binding of both drugs-but more notably of indoprofen-is very sensitive to variations of the environmental conditions. The binding is also dependent upon limited modifications in the tertiary structure of the protein. The evidences shown tend to indicate that these two phenomena are related, and that the binding is permitted under conditions of a relatively open structure of the protein molecule.
| Original language | English |
|---|---|
| Pages (from-to) | 1031-1037 |
| Number of pages | 7 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1986 |
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Keywords
- Anti-inflammatory drug binding
- Human serum albumin
- Indomethacin
- Indoprofen
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Effect of different parameters on the binding of two anti-inflammatory drugs to human serum albumin. / Zona, Cristina; Roscetti, Gianna; Venturelli, Francesca; Giorgio Roda, L.
In: Pharmacology, Biochemistry and Behavior, Vol. 24, No. 4, 1986, p. 1031-1037.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of different parameters on the binding of two anti-inflammatory drugs to human serum albumin
AU - Zona, Cristina
AU - Roscetti, Gianna
AU - Venturelli, Francesca
AU - Giorgio Roda, L.
PY - 1986
Y1 - 1986
N2 - The binding to human serum albunin of two anti-inflammatory drugs, indomethacin and indoprofen, has been studied by chromatographic and spectroscopic techniques. The results shown indicate that the binding of both drugs-but more notably of indoprofen-is very sensitive to variations of the environmental conditions. The binding is also dependent upon limited modifications in the tertiary structure of the protein. The evidences shown tend to indicate that these two phenomena are related, and that the binding is permitted under conditions of a relatively open structure of the protein molecule.
AB - The binding to human serum albunin of two anti-inflammatory drugs, indomethacin and indoprofen, has been studied by chromatographic and spectroscopic techniques. The results shown indicate that the binding of both drugs-but more notably of indoprofen-is very sensitive to variations of the environmental conditions. The binding is also dependent upon limited modifications in the tertiary structure of the protein. The evidences shown tend to indicate that these two phenomena are related, and that the binding is permitted under conditions of a relatively open structure of the protein molecule.
KW - Anti-inflammatory drug binding
KW - Human serum albumin
KW - Indomethacin
KW - Indoprofen
UR - http://www.scopus.com/inward/record.url?scp=0022534008&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022534008&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(86)90452-1
DO - 10.1016/0091-3057(86)90452-1
M3 - Article
VL - 24
SP - 1031
EP - 1037
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 4
ER -