Effect of different parameters on the binding of two anti-inflammatory drugs to human serum albumin

Cristina Zona; Gianna Roscetti; Francesca Venturelli; L. Giorgio Roda

doi:10.1016/0091-3057(86)90452-1

Effect of different parameters on the binding of two anti-inflammatory drugs to human serum albumin

Cristina Zona, Gianna Roscetti, Francesca Venturelli, L. Giorgio Roda

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The binding to human serum albunin of two anti-inflammatory drugs, indomethacin and indoprofen, has been studied by chromatographic and spectroscopic techniques. The results shown indicate that the binding of both drugs-but more notably of indoprofen-is very sensitive to variations of the environmental conditions. The binding is also dependent upon limited modifications in the tertiary structure of the protein. The evidences shown tend to indicate that these two phenomena are related, and that the binding is permitted under conditions of a relatively open structure of the protein molecule.

Original language	English
Pages (from-to)	1031-1037
Number of pages	7
Journal	Pharmacology, Biochemistry and Behavior
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(86)90452-1
Publication status	Published - 1986

Keywords

Anti-inflammatory drug binding
Human serum albumin
Indomethacin
Indoprofen

ASJC Scopus subject areas

Biochemistry
Behavioral Neuroscience
Pharmacology

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title = "Effect of different parameters on the binding of two anti-inflammatory drugs to human serum albumin",

abstract = "The binding to human serum albunin of two anti-inflammatory drugs, indomethacin and indoprofen, has been studied by chromatographic and spectroscopic techniques. The results shown indicate that the binding of both drugs-but more notably of indoprofen-is very sensitive to variations of the environmental conditions. The binding is also dependent upon limited modifications in the tertiary structure of the protein. The evidences shown tend to indicate that these two phenomena are related, and that the binding is permitted under conditions of a relatively open structure of the protein molecule.",

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AU - Zona, Cristina

AU - Roscetti, Gianna

AU - Venturelli, Francesca

AU - Giorgio Roda, L.

PY - 1986

Y1 - 1986

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AB - The binding to human serum albunin of two anti-inflammatory drugs, indomethacin and indoprofen, has been studied by chromatographic and spectroscopic techniques. The results shown indicate that the binding of both drugs-but more notably of indoprofen-is very sensitive to variations of the environmental conditions. The binding is also dependent upon limited modifications in the tertiary structure of the protein. The evidences shown tend to indicate that these two phenomena are related, and that the binding is permitted under conditions of a relatively open structure of the protein molecule.

KW - Anti-inflammatory drug binding

KW - Human serum albumin

KW - Indomethacin

KW - Indoprofen

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