Effect of diffusion-sensitizing gradient timings on the exponential, biexponential and diffusional kurtosis model parameters: In-vivo measurements in the rat thalamus

Ludovico Minati, Ileana Zucca, Gabriella Carcassola, Michele Occhipinti, Roberto Spreafico, Maria Grazia Bruzzone

Research output: Contribution to journalArticle

Abstract

Object: To investigate whether spacing (Δ) and duration (δ) of the diffusion-sensitizing gradient pulses differentially affect exponential (D′), biexponential (D slow, D fast and f slow) and diffusional kurtosis (D and K) model parameters. Methods: Measurements were performed in the rat thalamus for b = 200-3,200 s mm -2, sweeping Δ between 20 and 100 ms at δ = 15 ms, and δ between 15 and 50 ms at Δ = 60 ms. Linear regressions were performed for each model parameter vs. Δ or δ. Results: Increasing Δ from 20 to 100 ms increases D′ (from 0.64 to 0.70 × 10 -3 mm2s-1) and D slow (from 0.26 to 0.33 × 10-3 mm2s-1), reduces K (from 0.57 to 0.53), and has no effects on D fast, f slow or D. Increasing δ from 15 to 50 ms increases D (from 0.80 to 0.88 × 10-3 mm2s-1), and has no effects on the other parameters. Conclusion: The parameters of the biexponential and diffusional kurtosis models are more sensitive than the exponential model to Δ and δ; however, observed effects are too small to account for the discrepancies found in literature.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalMagnetic Resonance Materials in Physics, Biology, and Medicine
Volume23
Issue number2
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Biexponential model
  • Diffusion
  • Diffusional kurtosis model
  • Exponential model
  • Time

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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