Effect of dihydroxydibutylether (DHBE) on bile flow and composition in rats with ethynylestradiol-induced cholestasis

M. Podda, M. Zuin, M. L. Dioguardi, S. Festorazzi, C. Di Padova

Research output: Contribution to journalArticlepeer-review

Abstract

Administration of dihydroxydibutylether (DHBE, Dis-Cinil) to rats with ethynlestradiol(EE)-induced cholestasis provokes an increase in bile flow and output of bile acids and phospholipids. Since EE-induced cholestasis is related to the condition observed in humans, a clinical trial of DHRE in cholestatic syndromes seems worthwhile.

Original languageEnglish
Pages (from-to)2126-2128
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume30
Issue number12
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

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