Effect of dopamine infusion on serum prolactin concentration in normal and hyperprolactinemic subjects

E. Reschini, C. Ferrari, M. Peracchi, R. Fadini, M. Meschia, P. G. Crosignani

Research output: Contribution to journalArticlepeer-review

Abstract

The serum prolactin response to intravenous dopamine infusion (5 μg.kg -1.min -1) was measured in 21 healthy subjects, in 7 hyperprolactinemic patients without evidence of a pituitary tumor, and in 21 patients with prolactinomas. Mean serum values were significantly suppressed in all three groups, without any significant difference between the degree of suppression. A decrease of serum prolactin to below 50% of basal values occurred in 15 healthy subjects, in 4 patients without evidence of pituitary tumor, and in 14 patients with prolactinomas. These findings demonstrate that most human prolactin-secreting pituitary adenomas are normally suppressible by exogenously administered dopamine and that dopamine infusion is not able to distinguish between tumorous and non-tumorous hyperprolactinemia. Since intravenously infused dopamine is believed to inhibit prolactin secretion by acting at pituitary level, it is suggested that a normal functioning of pituitary dopamine receptors is maintained in most human prolactinomas.

Original languageEnglish
Pages (from-to)519-523
Number of pages5
JournalClinical Endocrinology
Volume13
Issue number6
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Endocrinology

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