Effect of dose-dense adjuvant chemotherapy in hormone receptor positive/HER2-negative early breast cancer patients according to immunohistochemically defined luminal subtype: an exploratory analysis of the GIM2 trial.

Benedetta Conte, Marco Bruzzone, Matteo Lambertini, Francesca Poggio, Claudia Bighin, Eva Blondeaux, Michelino De Laurentiis, Enrichetta Valle, Francesco Cognetti, Cecilia Nisticò, Sabino De Placido, Ornella Garrone, Teresa Gamucci, Filippo Montemurro, Fabio Puglisi, Barbara Cardinali, Piero Fregatti, Loredana Miglietta, Francesco Boccardo, Marcello CeppiLucia Del Mastro, GIM2 Investigators

Research output: Contribution to journalArticlepeer-review

Abstract

Luminal A-like and luminal B-like subtypes have different sensitivity to (neo)adjuvant chemotherapy, but their role in predicting dose-dense (DD) efficacy in the high-risk setting is unknown. In this exploratory analysis of the Gruppo Italiano Mammella 2 (GIM2) trial, we investigated DD efficacy according to luminal-like subtypes. Patients with node-positive early breast cancer were randomised to receive either DD or standard-interval (SI) anthracycline-based chemotherapy followed by paclitaxel. In our analysis, luminal A-like cohort was identified as having a Ki67 
Original languageUndefined/Unknown
Pages (from-to)43-51
Number of pages9
JournalEuropean Journal of Cancer
Volume136
DOIs
Publication statusPublished - Sep 1 2020

Keywords

  • Adult
  • Aged
  • 80 and over
  • Antineoplastic Combined Chemotherapy Protocols
  • administration & dosage
  • adverse effects
  • pharmacology
  • Breast Neoplasms
  • diagnosis
  • drug therapy
  • mortality
  • pathology
  • Chemotherapy
  • Adjuvant
  • Cohort Studies
  • Disease Progression
  • Dose-Response Relationship
  • Drug
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Neoplasm Staging
  • Phenotype
  • Prognosis
  • Receptor
  • ErbB-2
  • metabolism
  • Receptors
  • Estrogen
  • Progesterone
  • Survival Analysis
  • Breast cancer
  • Dose-dense chemotherapy
  • Hormone receptor-positive
  • Luminal subtype

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