Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension

Giuseppe Derosa, Arrigo F G Cicero, Angela D'Angelo, Carmine Tinelli, Leonardina Ciccarelli, Mario N. Piccinni, Fabio Pricolo, Sibilla Salvadeo, Lorenza Montagna, Alessia Gravina, Ilaria Ferrari, Simona Galli, Sonia Paniga, Roberto Fogari

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammation has been hypothesized to play a role in the development of hypertension. The high-sensitivity C-reactive protein (hs-CRP) is a well-studied marker of systemic inflammation that has a predictive power with regard to the development of hypertension. This study was designed to test the hypothesis that hs-CRP plasma levels are altered in hypertension. Moreover, the study was to assess whether chronic antihypertensive treatment with doxazosin would normalize hs-CRP and nitrites/nitrates. We measured plasma levels of hs-CRP and nitrites/nitrates in 44 normotensive subjects and in 44 patients with hypertension before and after doxazosin therapy for 4 months. hs-CRP plasma levels were significantly higher (P

Original languageEnglish
Pages (from-to)508-512
Number of pages5
JournalJournal of Cardiovascular Pharmacology
Volume47
Issue number4
DOIs
Publication statusPublished - Apr 2006

Keywords

  • Doxazosin
  • High sensitivity C-reactive protein
  • Hypertension
  • Inflammation
  • Nitrite/nitrate plasma levels

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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